Emergence of OXA-48-like producing species, Germany, 2011 to 2022.

BackgroundCarbapenemase-producing Enterobacterales are a public health threat worldwide and OXA-48 is the most prevalent carbapenemase in Germany and western Europe. However, the molecular epidemiology of OXA-48 in species other than and remains poorly understood.AimTo analyse the molecular epidemiology of OXA-48 and OXA-48-like carbapenemases in species (spp.

Incorporating a situational judgement test in residency selections: clinical, educational and organizational outcomes.

Background: Computer-based assessment for sampling personal characteristics (Casper), an online situational judgement test, is a broad measure of personal and professional qualities. We examined the impact of Casper in the residency selection process on professionalism concerns, learning interventions and resource utilization at an institution.

Methods: In 2022, admissions data and information in the files of residents in difficulty (over three years pre- and post- Casper implementation) was used to determine the number of residents in difficulty, CanMEDS roles requiring a learning intervention, types of learning interventions (informal learning plans vs.

Redefining Wound Healing Using Near-Infrared Spectroscopy.

Objective: No standard definition for a completely healed wound currently exists; it is recommended that providers use a reliable wound assessment tool to determine healing. The objective of this feasibility study was to determine if a point-of-care, noncontact, near-infrared (NIR) imaging device could provide an objective measure of wound resolution and guide clinical decision-making for the optimal time to transition from protective wound dressings and gradual return to full activity.

Methods: In this single-center feasibility study, adult patients 18 years and older with a lower extremity wound of any size and etiology were seen weekly for wound assessment and standard-of-care treatment.

Effects of a flotation vest and water flow rate on limb kinematics of Siberian Huskies swimming against a current.

Objective: To evaluate the effects of a flotation vest (FV) and water flow rate (WFR) on limb kinematics of dogs swimming against a current.

Animals: 7 (1 male and 6 female) healthy adult Siberian Huskies.

Procedures: Dogs were habituated to swim with and without an FV beside an investigator in a continuous-flow pool against WFRs up to 2.

Characteristics, predictors and outcomes among 99 patients hospitalised with COVID-19 in a tertiary care centre in Switzerland: an observational analysis.

Aims Of The Study: To describe admission characteristics, risk factors and outcomes of patients with coronavirus disease 2019 (COVID-19) hospitalised in a tertiary care hospital in Switzerland during the early phase of the pandemic.

Methods: This retrospective cohort study included adult patients with a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection confirmed by polymerase chain reaction (PCR) testing and hospitalised at the cantonal hospital Aarau (Switzerland) between 26 February 2020 and 30 April 2020. Our primary endpoint was severe COVID-19 progression defined as a composite of transfer to the intensive care unit (ICU) and in-hospital mortality.

Acute Toxicity and Quality of Life of Hypofractionated Radiation Therapy for Breast Cancer.

Purpose: To assess the acute toxicity and quality of life (QOL) of hypofractionation compared with conventional fractionation for whole breast irradiation (WBI) after breast-conserving surgery.

Methods And Materials: Women with node-negative breast cancer who had undergone breast-conserving surgery with clear margins were randomly assigned to conventional WBI of 5000 cGy in 25 fractions over 35 days or hypofractionated WBI of 4256 cGy in 16 fractions over 22 days. Acute skin toxicity and QOL were assessed at baseline and 2, 4, 6, and 8 weeks from the start of treatment for a subgroup of patients.

Addressing the Diversity-Validity Dilemma Using Situational Judgment Tests.

Purpose: To examine the magnitudes of score differences across different demographic groups for three academic (grade point average [GPA], old Medical College Admission Test [MCAT], and MCAT 2015) and one nonacademic (situational judgment test [SJT]) screening measures and one nonacademic (multiple mini-interview [MMI]) interview measure (analysis 1), and the demographic implications of including an SJT in the screening stage for the pool of applicants who are invited to interview (analysis 2).

Method: The authors ran the analyses using data from New York Medical College School of Medicine applicants from the 2015-2016 admissions cycle. For analysis 1, effect sizes (Cohen d) were calculated for GPA, old MCAT, MCAT 2015, CASPer (an online SJT), and MMI.

Pain Palliation Using Hypofractionated Radiotherapy for Unresectable Pancreatic Cancer.

Background: Pain is a common symptom for patients with pancreatic cancer and is often treated using palliative radiation therapy. Standard palliative dose regimes typically consist of 2000 cGy to 3000 cGy in 5 to 10 fractions (fx). With the recent advancements in radiation dosimetric planning and delivery, the Juravinski Cancer Centre in Hamilton, Ontario, offers a hypofractionated dose of 2500 cGy in 5 fx for the improvement of pain and tumour control in selected pancreatic cancer patients.

Simultaneous resection of colorectal cancer with synchronous liver metastases (RESECT), a pilot study.

Introduction: The "traditional approach" to resect synchronous colorectal cancer with liver metastases (CRLM) is to perform staged resections. Many institutions perform simultaneous resection. Disadvantages to the simultaneous approach include longer operating room times, which may increase major postoperative complication rates.

Interaction of industrially relevant cationic starches with cellulose.

Industrially relevant, commercially available cationic starches have been investigated towards their interaction capacity with cellulose thin films derived from trimethylsilyl cellulose (TMSC). The starches used in this study stem from different sources (potato, pea, corn) and featured rather low degrees of substitution ranging from 0.030 to 0.

Vive la Différence: The Freedom and Inherent Responsibilities When Designing and Implementing Multiple Mini-Interviews.

The literature on multiple mini-interviews (MMIs) is replete with heterogeneous study results related to the constructs measured, correlations with other measures, and demographic relationships. Rather than view these results as contradictory, the authors ask, What if all of the results are correct? They point out that the MMI is not an assessment tool but, rather, an assessment method. Design and implementation of locally conducted MMIs in medical school admissions processes should reflect local needs.

Correction to: CASPer, an online pre-interview screen for personal/professional characteristics: prediction of national licensure scores.

In re-examining the paper "CASPer, an online pre-interview screen for personal/professional characteristics: prediction of national licensure scores" published in AHSE (22(2), 327-336), we recognized two errors of interpretation.

CASPer, an online pre-interview screen for personal/professional characteristics: prediction of national licensure scores.

Typically, only a minority of applicants to health professional training are invited to interview. However, pre-interview measures of cognitive skills predict for national licensure scores (Gauer et al. in Med Educ Online 21 2016) and subsequently licensure scores predict for performance in practice (Tamblyn et al.

Early Indication of Decompensated Heart Failure in Patients on Home-Telemonitoring: A Comparison of Prediction Algorithms Based on Daily Weight and Noninvasive Transthoracic Bio-impedance.

Background: Heart Failure (HF) is a common reason for hospitalization. Admissions might be prevented by early detection of and intervention for decompensation. Conventionally, changes in weight, a possible measure of fluid accumulation, have been used to detect deterioration.

The Effect of Differential Weighting of Academics, Experiences, and Competencies Measured by Multiple Mini Interview (MMI) on Race and Ethnicity of Cohorts Accepted to One Medical School.

Purpose: To examine whether academic scores, experience scores, and Multiple Mini Interview (MMI) core personal competencies scores vary across applicants' self-reported ethnicities, and whether changes in weighting of scores would alter the proportion of ethnicities underrepresented in medicine (URIM) in the entering class composition.

Method: This study analyzed retrospective data from 1,339 applicants to the Rutgers Robert Wood Johnson Medical School interviewed for entering classes 2011-2013. Data analyzed included two academic scores-grade point average (GPA) and Medical College Admission Test (MCAT)-service/clinical/research (SCR) scores, and MMI scores.

Leaving home in Slovenia: a quantitative exploration of residential independence among young adults.

The present paper analyzes and contextualizes the phenomenon of prolonged co-residence of parents and young adult children in Slovenia. It analyzes the process of moving out or staying at home on the basis of a subsample of young people between 19 and 29 who are no longer at school included in the representative Slovenian field survey Youth 2010. Young people still living in the household of their parents or (legal) guardians are compared with those who have already left.

Disease spectrum in patients with elevated serum tryptase levels.

Background: Elevated serum tryptase levels can be a sign of mastocytosis, which is a rare disease associated with systemic and/or skin manifestations.

Objective: To investigate patients with elevated tryptase levels in regard to their underlying diseases, and to determine whether increased tryptase can be used as a diagnostic marker for underlying mastocytosis.

Methods: In a retrospective study the data of 96 patients with serum tryptase levels higher than 15 μg/L were systematically analysed.

HeartCycle: from insights to clinically evaluated ICT solutions for Telehealth.

HeartCycle is a large European Integrated Project (IP) and develops technologies and services for Telehealth, which is to remotely monitor and manage patients at home and motivate them to be compliant to treatment regimens and to a beneficial lifestyle. Telehealth allows healthcare professionals to better control the progress of the therapy, detect upcoming adverse events early and react in time with personalized care plan adjustments, leading to prevent relapses, stabilizing the patient and avoid costly hospitalizations.

Association between a medical school admission process using the multiple mini-interview and national licensing examination scores.

Context: There has been difficulty designing medical school admissions processes that provide valid measurement of candidates' nonacademic qualities.

Objective: To determine whether students deemed acceptable through a revised admissions protocol using a 12-station multiple mini-interview (MMI) outperform others on the 2 parts of the Canadian national licensing examinations (Medical Council of Canada Qualifying Examination [MCCQE]). The MMI process requires candidates to rotate through brief sequential interviews with structured tasks and independent assessment within each interview.