Nutrient Digestibility and Retention of Potential Feed Ingredients for Rainbow Trout ( W.) Aquaculture in Iran.

To overcome the aquafeed challenges for aquaculture in Iran, the world's largest rainbow trout producer, the nutrient digestibility and retention of eight rendered poultry by-products, and two plant protein sources were investigated. The test ingredients were added to a casein-based semipurified reference diet as control diet and fed to juvenile rainbow trout in three runs. During the experimental runs, test ingredients were added to the control diet in a ratio of 30 : 70.

A Fast and Highly Stable Aqueous Calcium-Ion Battery for Sustainable Energy Storage.

Aqueous alkali-ion batteries are gaining traction as a low-cost, sustainable alternative to conventional organic lithium-ion batteries. However, the rapid degradation of commonly used electrode materials, such as Prussian Blue Analogs and carbonyl-based organic compounds, continues to challenge the economic viability of these devices. While stability issues can be addressed by employing highly concentrated water-in-salt electrolytes, this approach often requires expensive and, in many cases, fluorinated salts.

Training in medical communication competence through video-based e-learning: How effective are video modeling and video reflection?

Objective: The present study investigated the efficacy of the didactic approaches of video modeling (VM, best-practice examples), video reflection (VR, problem-based approach), and the combination of both (VMR) in fostering medical communication competence in a video-based digital learning environment.

Methods: N = 126 third-year medical students who participated in the pre-post study were assigned to either the intervention groups (VM, VR, and VMR) or the wait-list control group. The efficacy of the three approaches was assessed by means of a situational judgment test (SJT) of medical communication competence.

Internet-Delivered Cognitive Behavioral Therapy Tailored to Spouses and Significant Others of Public Safety Personnel: Formative Evaluation Study.

Background: Spouses and significant others (SSOs) of public safety personnel (PSP) are affected by the risks and requirements of these occupations. Internet-delivered cognitive behavioral therapy (ICBT) provides a convenient and accessible treatment format that can be tailored to the needs of SSOs of PSP.

Objective: This study aimed to assess the initial use and client perceptions (eg, likes, helpfulness, and areas for improvement) of a self-guided, transdiagnostic ICBT course designed for Canadian SSOs of PSP and identify opportunities to further tailor ICBT for this group.

The African-centric P47S Variant of Confers Immune Dysregulation and Impaired Response to Immune Checkpoint Inhibition.

Unlabelled: The tumor suppressor is the most frequently mutated gene in cancer and is mutationally inactivated in 50% of sporadic tumors. Inactivating mutations in also occur in Li Fraumeni syndrome (LFS). In addition to germline mutations in in LFS that completely inactivate this protein, there are many more germline mutant forms of in human populations that partially inactivate this protein: we call these partially inactivating mutations "hypomorphs.

Predictors for Survival of Patients with Squamous Cell Carcinoma of Unknown Primary in the Head and Neck Region.

Background: Human papillomavirus (HPV) status is the most important predictor of survival in oropharyngeal squamous cell carcinoma (OPSCC). In patients with cervical lymph node metastases of squamous cell carcinoma of unknown origin (CUP), much less is known.

Methods: We assessed a consecutive cohort of CUP diagnosed from 2000-2018 for HPV DNA, mRNA, p16 (p16) expression, and risk factors to identify prognostic classification markers.

IgA Plasma Cells Are Long-Lived Residents of Gut and Bone Marrow That Express Isotype- and Tissue-Specific Gene Expression Patterns.

Antibody secreting plasma cells are made in response to a variety of pathogenic and commensal microbes. While all plasma cells express a core gene transcription program that allows them to secrete large quantities of immunoglobulin, unique transcriptional profiles are linked to plasma cells expressing different antibody isotypes. IgA expressing plasma cells are generally thought of as short-lived in mucosal tissues and they have been understudied in systemic sites like the bone marrow.

A novel hyperbaric swimming respirometer allows the simulation of varying swimming depths in fish respirometry studies.

The understanding of swimming physiology and knowledge on the metabolic costs of swimming are important for assessing effects of environmental factors on migratory behavior. Swim tunnels are the most common experimental setups for measuring swimming performance and oxygen uptake rates in fishes; however, few can realistically simulate depth and the changes in hydrostatic pressure that many fishes experience, e.g.

A video-based situational judgement test of medical students' communication competence in patient encounters: Development and first evaluation.

Objective: We developed and evaluated the Video-Based Assessment of Medical Communication Competence (VA-MeCo), a construct-driven situational judgement test measuring medical students' communication competence in patient encounters.

Methods: In the construction phase, we conducted two expert studies (n = 6, n = 13) to ensure curricular and content validity and sufficient expert agreement on the answer key. In the evaluation phase, we conducted a cognitive pre-test (n = 12) and a pilot study (n = 117) with medical students to evaluate test usability and acceptance, item statistics and test reliability depending on the applied scoring method (raw consensus vs.

Profiling and Characterization of Localized Cytokine Response in Congenital Cleft Affected Lip Tissue.

(1) Background: Despite cleft lips and palates belonging to the most common orofacial congenital anomalies, their morphopathogenesis is not yet fully understood. The study aimed to determine the distribution and relation of cytokines interferon-γ (IFN-γ), tumor necrosis factor-alpha (TNF-α), interleukin (IL)-2, IL-7, IL-12, and IL-13 in the cleft affected mucosa of the lip. (2) Materials and Methods: Twenty cleft lip (CL) mucosal samples and seven control tissues of oral cavity mucosa were included in the study.

Internal Jugular Vein Thrombosis: Unusual Diagnosis of a Cervical Mass.

Idiopathic internal jugular vein thrombosis (IJVT) is a rarity that we must quickly identify and manage, as it may have severe consequences such as cerebral venous sinus thrombosis (CVST). CVST might be fatal unless it is managed promptly. However, due to its rarity, clinicians are often unfamiliar with the presentation of this pathology.

Environmental enrichment during early rearing provokes epigenetic changes in the brain of a salmonid fish.

Environmental enrichment is used to increase structural complexity of captive rearing systems and has been shown to provoke a wide range of effects in the kept animals. Here we studied the effects of enrichment on DNA methylation patterns at the whole-genome level in the brain of rainbow trout reared in an aquaculture setting. We investigated the epigenetic effects between different types of enrichment (natural substrate vs.

How can communicative competence instruction in medical studies be improved through digitalization?

The teaching of communicative competence plays an increasingly important role in medical education. In addition to traditional teaching formats, such as role-plays with simulated patients, technology-based approaches become more important in medical education. Teaching materials are increasingly augmented by videos of simulated doctor-patient conversations.

Examining the relationships between childhood abuse history, attachment, and health anxiety.

This study examined the relationship between childhood abuse experiences and health anxiety in adulthood and investigated the role of attachment in this relationship. In total, 181 university students (aged 18-29 years) completed a battery of measures that assessed childhood abuse, health anxiety, and attachment orientation. Health anxiety was associated with all categories of childhood abuse and overall childhood abuse severity.

Fetal health anxiety: development and psychometric properties of the fetal health anxiety inventory.

To develop a measure to assess fetal health anxiety and examine its factor structure, convergent and divergent validity. In Study 1, the Short Health Anxiety Inventory-14 item version (SHAI) (Salkovskis et al., Psychol Med.

Making Together: An Interdisciplinary, Inter-institutional Assistive-Technology Project.

Faculty at the University of North Carolina Asheville partnered with local healthcare professionals and retirement home residents and administrators on an assistive-technology project. The Creative Fabrication introductory computer science course incorporated subject-matter experts from the healthcare community, older and differently abled "users," medical students, and sculpture faculty. Over the semester, the class students created assistive devices to meet the needs of the retirement home residents.

A Mobile App for the Self-Management of Type 1 Diabetes Among Adolescents: A Randomized Controlled Trial.

Background: While optimal blood glucose control is known to reduce the long-term complications associated with type 1 diabetes mellitus, adolescents often struggle to achieve their blood glucose targets. However, their strong propensity toward technology presents a unique opportunity for the delivery of novel self-management interventions. To support type 1 diabetes self-management in this population, we developed the diabetes self-management app bant, which included wireless blood glucose reading transfer, out-of-range blood glucose trend alerts, coaching around out-of-range trend causes and fixes, and a point-based incentive system.

Metamorphosis and transition between developmental stages in European eel (Anguilla anguilla, L.) involve epigenetic changes in DNA methylation patterns.

The life history of the European eel (Anguilla anguilla, L.) is characterized by a series of metamorphoses and transitions that provoke drastic morphological changes. Most of these changes go along with the catadromous life cycle in eels, involving extensive physiologically adaptations.

Solvent activity in electrolyte solutions from molecular simulation of the osmotic pressure.

A method for determining the activity of the solvent in electrolyte solutions by molecular dynamics simulations is presented. The electrolyte solution is simulated in contact with the pure solvent. Between the two phases, there is a virtual membrane, which is permeable only for the solvent.

The relationship between childhood health anxiety, parent health anxiety, and associated constructs.

The purpose of the present investigation was to explore the relationship between self-reported childhood health anxiety and self-reported parent health anxiety and associated constructs. Participants were 77 children (8-15 years) and one parent or guardian of each child. Children completed a measure of health anxiety and parents completed measures of health anxiety, anxiety sensitivity, and depression.

Hydrostatic pressure affects selective tidal stream transport in the North Sea brown shrimp (Crangon crangon).

The brown shrimp (Crangon crangon) is a highly abundant invertebrate in the North Sea, with its life cycle stages ranging from deep offshore spawning to shallow onshore nursery areas. To overcome the long distances between these two habitats, brown shrimp are suspected to use selective tidal stream transport (STST), moving with the cyclic tide currents towards their preferred water depths. However, it is not known which stimulus actually triggers STST behavior in brown shrimp.

The "Iceberg Phenomenon": As Soon as One Technological Problem in NOTES Is Solved, the Next One Appears!

Purpose: Though already proclaimed about 7 years ago, natural orifice transluminal endoscopic surgery (NOTES) is still in its early stages. A multidisciplinary working team tried to analyze the technical obstacles and identify potential solutions.

Methods: After a comprehensive review of the literature, a group of 3 surgeons, 1 gastroenterologist, 10 engineers, and 1 representative of biomedical industry defined the most important deficiencies within the system and then compiled as well as evaluated innovative technologies that could be used to help overcome these problems.

Molecular dispersion energy parameters for alkali and halide ions in aqueous solution.

Thermodynamic properties of aqueous solutions containing alkali and halide ions are determined by molecular simulation. The following ions are studied: Li(+), Na(+), K(+), Rb(+), Cs(+), F(-), Cl(-), Br(-), and I(-). The employed ion force fields consist of one Lennard-Jones (LJ) site and one concentric point charge with a magnitude of ±1 e.