National Consensus on Contraindications for Corneal Donation for Transplantation in Switzerland.

Purpose: To establish a national consensus on contraindications for corneal donation for transplantation in Switzerland.

Methods: Swisstransplant (SWT), the Swiss national foundation coordinating tissue and organ donations, convened a working group consisting of six national corneal surgeons and eye bankers and donation experts to create a contraindication list for corneal donation. The group reviewed available national and international guidelines and recommendations, while adhering to Swiss law and transplant regulations.

[The 2021 Activity Report of the Tissue Transplantation and Biotechnology Section of the German Ophthalmological Society].

The Section on Tissue Transplantation and Biotechnology of the German Ophthalmologic Society presented its 11th annual report for the year 2021. The number of corneal samples has still risen in comparison to former years. Nevertheless, there is still a need for import of transplants from abroad.

[The 2018 Activity Report of the Tissue Transplantation and Biotechnology Section of the German Ophthalmological Society].

The Section on Tissue Transplantation and Biotechnology presented its 9th annual report. On the one hand, the number of cornea samples has risen to 10,840, of which 7168 have been transplanted. On the other hand, 1340 transplants have still been imported from abroad and more than 3300 patients were waiting for a transplant at the end of the year.

Rejection Prophylaxis in Corneal Transplant.

Background: Graft rejection. Twenty to thirty percent of patients with corneal transplants experience at least one rejection episode in the first 5 years after transplantation. Prophylaxis through matching for human leukocyte antigens (HLA) is controversial.

Trends in Corneal Transplantation from 2001 to 2016 in Germany: A Report of the DOG-Section Cornea and its Keratoplasty Registry.

Purpose: The purpose of this retrospective panel study was to provide an overview of absolute numbers and of trends in the types of and indications for corneal transplantation in Germany from 2001 to 2016.

Methods: A questionnaire about absolute numbers, types of transplantation, and indications was sent to 111 ophthalmologic departments in Germany, out of which 94 (85%) provided their data.

Results: Since the year 2001, the number of corneal transplantations has increased by 1.

Simultaneous transplantation of limbal stem cells may reduce recurrences of granular dystrophy after corneal transplantation: 2 long-term case reports.

To present 2 cases with long-term relapse-free intervals only after limbo-keratoplasty but not after conventional penetrating keratoplasty in granular dystrophy.Retrospective review of the patient charts and photographs taken during long-term follow-up of 2 cases with granular dystrophy, in which 1 eye received penetrating keratoplasty and the fellow eye received penetrating limbo-keratoplasty.In the first patient, 1 eye showed extensive recurrence of granular deposits 17 years after penetrating keratoplasty was performed while in the second eye two-thirds of the corneal transplant adjacent to the transplanted limbal area remained clear 12 years after the limbo-corneal transplant.

[Conservative treatment of dry eye].

The use of topic anti-inflammatory drugs has become very important in the treatment of dry eye disease. Besides the basic therapy including tear replacement, use of serum eye drops and mucolytic eye drops, the topical application of corticosteroids and cyclosporin A is more commonly used in moderate to severe forms of dry eye disease. The consistent treatment of Meibomian gland dysfunction as a frequent reason for evaporative dry eye is also of particular importance.

[DMEK in corneal endothelial disorders: first Swiss consecutive series].

Purpose: The aim of this study was to analyse clinical and functional results after Descemet membrane endothelial keratoplasty (DMEK) as preferred technique in patients with Fuchs dystrophy and endothelial decompensation in a consecutive series.

History And Signs: In 12 eyes of 11 patients with Fuchs dystrophy or postoperative corneal decompensation a Descemet membrane endothelial keratoplasty as sole technique was indicated. All eyes were pseudophakic.

Total protein concentration and T-cell suppression activity of aqueous humour before and after penetrating keratoplasty.

Purpose: We wished to determine whether immune privilege parameters assayed in aqueous humour (AqH) are relevant to the fate of penetrating keratoplasty (PK) in humans.

Methods: AqH was collected in 28 patients before PK (prospective cohort), in 6 patients with no history of graft rejection undergoing cataract surgery after PK (acceptors), in another 6 patients undergoing treatment of an acute endothelial immune reaction (rejectors), and in 65 controls undergoing uncomplicated cataract extraction. AqH was tested for total protein concentration and the ability to suppress T-cell activation.

[The 2009 performance report of the German cornea banks].

Background: In Germany, human tissue for corneal and amniotic transplantation is supplied by 27 cornea banks.

Methods: The Section for Tissue Transplantation and Biotechnology of the German Ophthalmological Society records the cornea banks' activities by means of an annual questionnaire.

Results: In 2009, a total of 4,818 corneal grafts were processed by 21 responding cornea banks, and 57% were deemed suitable for transplantation.

Corneal surface reconstruction using adult mesenchymal stem cells in experimental limbal stem cell deficiency in rabbits.

Purpose: To investigate the ability of mesenchymal stem cells (MSC) to transdifferentiate to corneal epithelial cells in experimental limbal stem cell deficiency in rabbits.

Methods: Total limbal stem cell deficiency was produced in 21 right eyes of 21 New Zealand rabbits; 6 eyes served as controls (group 1, G1). After removal of the conjunctival overgrowth, five eyes received amniotic membrane transplantation (AMT; G2).

[Experimental studies on the schistosomicidal activity of the aminobenzaldehyde derivative 80.647 (author's transl)].

In a group of aminobenzaldehyde derivatives the 2-cholor-4-(1)-piperazinobenalazine showed to be highly active in golden hamsters (Mesocricetus auratus), Mastomys natalensis and capucine monkeys (Cebus capucinus capucinus) against Schistosoma mansoni, slightly active against S. mattheei and inactive against S. haematobium and S.

New pleuromutilin derivatives with enhanced antimicrobial activity.II.Structure-activity correlations.

Structural modification of the antibiotic pleuromutilin has afforded several derivatives with considerably enhanced activity against bacteria and mycoplasmas, and has permitted conclusions to be reached about structure-activity relationships. The carbonyl group in the five-membered ring and the hydroxyl group at C11 seem to be essential for activity. The vinyl group can be hydrogenated without loss of activity.