The inflow rate of low density lipoprotein cholesterol to the arterial wall in experimental atherosclerosis.

The in vivo inflow rate of low density lipoprotein (LDL) cholesterol to the thoracic aorta, renal and coronary arteries was studied in minipigs with endogenously labelled 3H-cholesterol LDL. The LDL cholesterol inflow rate to these arteries was three to five times higher in animals with hypercholesterolemia and experimental atherosclerosis compared to the controls. Moreover, the inflow rate of LDL cholesterol to the control intact arteries was so high that the cumulation of arterial cholesterol cannot be regarded simply as one-way transport and the amount of cholesterol present in the arterial wall is the result of the equilibrium between LDL cholesterol inflow and transport out from the wall.

Epidemiology and prevention of ischaemic heart disease in automobile industry workers.

Following on the epidemiological study of cardiovascular diseases carried out in the rural population of Northern Bohemia in 1970 a long-term ischaemic heart disease prevention programme was launched in a group of 2582 men aged between 30-59 years, worked of two automobile plants in the district of Mladá Boleslav. Under der programme "Protected Your Heart", sponsored by the Automobile Works National Enterprise (AZNP), workers were urged to adjust their food intake in keeping with the principles of rational nutrition, to stop smoking and to take regular after-work cross-country 4 km/1 hr walks. No such programme was carried out at the automobile plant LIAZ serving as control.