Drug interactions in the treatment of rheumatoid arthritis and psoriatic arthritis.

Background: Treating patients with inflammatory joint diseases (rheumatoid arthritis, psoriatic arthritis) according to established treatment algorithms often requires the simultaneous use of three or more medications to relieve symptoms and prevent long-term joint damage as well as disability.

Objective: To assess and give an overview on drug-drug interactions in the pharmacotherapy of inflammatory joint diseases with regards to their clinical relevance.

Methods: All possible drug combinations were evaluated using three commercially available drug interaction programs.