Transdermal absorption of ethanol- and 1-propanol-containing hand disinfectants.

Background And Aims: Ethanol- or 1-propanol-containing hand disinfectants are widely used as surgical hand antisepsis. The primary objective of this study was to investigate transdermal absorption of ethanol and 1-propanol from combination of 45% ethanol and 18% 1-propanol with skin protecting ingredients (Softa-Man®) within 1 h after application in comparison to the absorption of these alcohols from the product in the absence of the cosmetic additives. The secondary objective was to evaluate the dermal tolerability.

Transdermal resorption of an ethanol- and 2-propanol-containing skin disinfectant.

Background And Aims: Ethanol- or 2-propanol-containing disinfectant agents are widely used in medical practice, particularly in the surgical environment. It was the primary objective of this phase I study to comparatively investigate the transdermal resorption of ethanol and 2-propanol within 1 h after dermal application of the two agents as single preparations and a commercial product containing both alcohols in combination, respectively. The secondary objective was to examine whether a mutual influence of the two alcohols in combination exists.

Polyvinyl alcohol gel prevents abdominal adhesion formation in a rabbit model.

Objective: To evaluate the function and biocompatibility of the new adhesion barrier PVA gel (polyvinyl alcohol + carboxymethylated cellulose) in the prevention of postsurgical peritoneal adhesions in a rabbit sidewall model. To evaluate and compare the routinely used 4% icodextrin.

Design: A prospective randomized controlled study was designed to evaluate the effectiveness of PVA gel in reducing postoperative adhesion formation.