Comparable sensitivities of urine cotinine and breath carbon monoxide at follow-up time points of three months or more in a smoking cessation trial.

To control for likely overreporting of abstinence in clinical trials of smoking cessation aids, field convention demands the corroboration of subjects' self-reports by a biochemical/pharmacological marker. It is, however, currently debated if urinary cotinine (UC), a metabolite of nicotine, should be preferred because of its higher sensitivity, although sample collection for and analysis of cotinine are much more expensive and work intensive than carbon monoxide (CO) measurements in exhaled air. In the present study, it turned out that UC was of only moderately higher sensitivity than CO (99.

A randomized trial of short psychotherapy versus sustained-release bupropion for smoking cessation.

Aims: To compare the efficacy and safety of a novel psychological intervention for smoking cessation called psychodynamic model (PDM) training to an active control condition of sustained-release bupropion.

Design: Randomized controlled clinical trial with allocation concealment.

Setting: Private psychiatric practice.