Publications by authors named "Reingsey Samreth"
We assessed the efficacy of standard 3-day courses of chloroquine and dihydroartemisinin/piperaquine against Plasmodium vivax malaria. Compared with chloroquine, dihydroartemisinin/piperaquine was faster in clearing asexual P. vivax parasites and blocking human-to-mosquito transmission.
View Article and Find Full Text PDFBackground: Eliminating falciparum malaria in Cambodia is a top priority, requiring the implementation of novel tools and strategies to interrupt its transmission. To date, few data are available regarding the contributions to malaria transmission of symptomatic and asymptomatic carriers.
Methods: Direct-membrane and skin feeding assays (DMFAs, SFAs) were performed, using Anopheles minimus and Anopheles dirus, to determine infectivity of symptomatic falciparum-infected patients and malaria asymptomatic carriers; a subset of the latter were followed up for 2 months to assess their transmission potential.
Article Synopsis
- Researchers face challenges in studying Plasmodium vivax due to the difficulty of maintaining long-term lab cultures, leading to reliance on patient samples with low parasite quantities.
- This study presents RNA-seq data from three Cambodian malaria patients, revealing consistent gene expression patterns in the parasites despite varying stages of infection.
- The findings suggest that over 10% of P. vivax genes encode multiple protein-coding sequences and enhance the understanding of gene untranslated regions, offering valuable insights for future research.