Publications by authors named "Reindl M"
Background: Fulminant idiopathic intracranial hypertension (IIH) is characterized by headache, rapid decrease of vision and elevated CSF-opening pressure.
Objective: To delineate a subgroup of MOGAD mimicking fulminant IIH.
Methods: In this case series children with MOGAD with vision loss, optic disc swelling and elevated CSF opening pressure, initially diagnosed with fulminant IIH, were included.
Background: The presence and clinical significance of hepatic tissue alterations as assessed by cardiac magnetic resonance imaging in patients with ST-segment-elevation myocardial infarction (STEMI), are unclear. This study aimed to investigate associations of hepatic T1 patterns with myocardial tissue damage and clinical outcomes in patients suffering from STEMI.
Methods: We analyzed 485 patients with STEMI treated with percutaneous coronary intervention who were enrolled in the prospective MARINA STEMI study (Magnetic Resonance Imaging In Acute ST-Elevation Myocardial Infarction).
Long-term follow-up MR imaging in children with transverse myelitis.
Mult Scler Relat Disord
December 2024
Article Synopsis
- The study investigates how lesions in children with transverse myelitis (TM) resolve over time, focusing on different related diseases: MOG-antibody associated disorders (MOGAD), multiple sclerosis (MS), neuromyelitis optica spectrum disorders (NMOSD), and double seronegative TM.
- A total of 78 children from various medical centers were assessed, and a grading system was used to measure the resolution of lesions over time.
- Results showed that MOGAD had the fastest and most complete resolution of lesions, followed by double seronegative TM, MS, and NMOSD, with none of the NMOSD patients achieving complete resolution during the observation period.
Background: Beyond therapeutic implications, PCSK9 (proprotein convertase subtilisin/kexin 9) has emerged as a promising cardiovascular biomarker. The exact role of PCSK9 in the setting of acute ST-elevation myocardial infarction (STEMI) is incompletely understood. We aimed to investigate the association of PCSK9 with ischemia-reperfusion injury, visualized by cardiac magnetic resonance imaging, in patients with STEMI revascularized by primary percutaneous coronary intervention (PCI).
View Article and Find Full Text PDFBackground: Actual and imagined cued gait trainings have not been compared in people with multiple sclerosis (MS).
Objective: To analyze the effects of cued motor imagery (CMI), cued gait training (CGT), and combined CMI and cued gait training (CMI-CGT) on motor, cognitive, and emotional functioning, and health-related quality of life in people with MS.
Methods: In this double-blind randomized parallel-group multicenter trial, people with MS were randomized (1:1:1) to CMI, CMI-CGT, or CGT for 30 minutes, 4×/week for 4 weeks.
Article Synopsis
- Researchers studied the inflammatory response in 173 patients with acute ischaemic stroke by measuring 65 cytokines and chemokines in their plasma, finding varied profiles based on inflammatory levels.
- Stroke patients showed higher levels of compounds like HGF and SDF-1α and lower IL-4 compared to those with spontaneous cervical artery dissection, suggesting different inflammatory responses.
- The analysis revealed that stroke from large artery atherosclerosis, cardioembolism, and small vessel occlusion leads to a greater inflammatory response than spontaneous cervical artery dissection, with stable cytokine levels over time.
Background: The prognostic significance of various microvascular injury (MVI) patterns after ST-segment elevation myocardial infarction (STEMI) is not well known.
Objectives: This study sought to investigate the prognostic implications of different MVI patterns in STEMI patients.
Methods: The authors analyzed 1,109 STEMI patients included in 3 prospective studies.
Article Synopsis
- The study focuses on comparing blood parameters in children with myelin oligodendrocyte glycoprotein antibody-associated disorders (MOGAD), AQP4-IgG-positive neuromyelitis optica spectrum disorders (NMOSD), multiple sclerosis (MS), and healthy controls to better understand disease activity.
- Researchers analyzed complete blood counts and various ratios (like NLR and PLR) during different disease phases: clinical attack, acute treatment, and remission across a cohort of 174 children and adolescents.
- Key findings revealed elevated leukocyte counts in MOGAD during clinical attacks, while other blood parameters like NLR and PLR showed different trends, suggesting these measures could aid in assessing disease activity and distinguishing between disease
Cardiac remodelling patterns in hypertension: does ethnicity matter?
Eur Heart J Cardiovasc Imaging
June 2024
Article Synopsis
- Myelin oligodendrocyte glycoprotein antibody-associated encephalomyelitis (MOG-EM) is an important condition to differentiate from multiple sclerosis and neuromyelitis optica, with new diagnostic criteria emphasizing specific antibody testing.
- This study evaluated the effectiveness of using MOG-IgG3-specific testing in addition to standard tests for detecting MOG antibodies in patients previously identified as having MOG-EM.
- Results showed that MOG-IgG3 could improve the sensitivity of tests, as 52% of patients still displayed positive MOG-IgG3 results, indicating it may be a crucial subclass in diagnosing MOG-EM, despite its absence in healthy controls or
Background: Mitral annular disjunction (MAD), defined as defective attachment of the mitral annulus to the ventricular myocardium, has recently been linked to malignant arrhythmias. However, its role and prognostic significance in patients requiring cardiopulmonary resuscitation (CPR) remain unknown. This retrospective analysis aimed to describe the prevalence and significance of MAD by cardiac magnetic resonance (CMR) imaging in out-of-hospital cardiac arrest (OHCA) patients.
View Article and Find Full Text PDFArticle Synopsis
- Recent studies suggest that myelin oligodendrocyte glycoprotein antibody-associated disease could be a rare complication linked to either SARS-CoV-2 infection or vaccination.
- The research aims to determine if there's an immune response overlap between SARS-CoV-2 proteins and myelin oligodendrocyte glycoprotein, which could explain the condition's occurrence.
- Serum samples from various groups with different histories of SARS-CoV-2 infection and neurological symptoms were analyzed to assess antibody responses against both myelin oligodendrocyte glycoprotein and SARS-CoV-2, among other common coronaviruses.
Article Synopsis
- The study investigates the link between plasma neuropeptide-Y (NPY) levels and heart muscle function in patients who suffered from a ST-elevation myocardial infarction (STEMI) and were treated with a procedure called primary percutaneous coronary intervention (PCI).
- Results show that higher NPY levels are connected to poorer heart function indicators, such as lower left ventricular ejection fraction (LVEF) and global longitudinal strain (GLS), as well as larger infarct sizes (IS) and microvascular obstruction (MVO).
- The findings suggest that elevated NPY levels after a heart attack might be an important marker for evaluating heart damage and recovery prospects, independent of other clinical factors.
Article Synopsis
- Body fluid markers can help predict the progression to clinically definite multiple sclerosis (MS) in individuals experiencing their first demyelinating event in the central nervous system (CNS).
- The review analyzes the potential of various biomarkers to forecast MS conversion, monitor disease activity, and differentiate MS from similar disorders like neuromyelitis optica spectrum disorder.
- Recent advancements in research have highlighted both established (e.g., oligoclonal bands) and emerging biomarkers (e.g., neurofilament light), although challenges remain in monitoring these markers, particularly those only found in cerebrospinal fluid.
Iron-containing metal-organic frameworks are promising Fenton catalysts. However, the absence of additional modifiers has proven difficult due to the low reaction rates and the inability to manipulate the catalysts. We hypothesize that the production of iron oxide NPs in the presence of a metal-organic framework will increase the rate of the Fenton reaction and lead to the production of particles that can be magnetically manipulated without changing the structure of the components.
View Article and Find Full Text PDFBackground: Microvascular obstruction (MVO) and intramyocardial hemorrhage (IMH) are well-established imaging biomarkers of failed myocardial tissue reperfusion in patients with ST-segment elevation-myocardial infarction treated with percutaneous coronary intervention. MVO and IMH are associated with an increased risk of adverse outcome independent of infarct size, but whether the size of the culprit lesion vessel plays a role in the occurrence and severity of reperfusion injury is currently unknown. This study aimed to evaluate the association between culprit lesion vessel size and the occurrence and severity of reperfusion injury as determined by cardiac magnetic resonance imaging.
View Article and Find Full Text PDFAutoantibody status, neuroradiological and clinical findings in children with acute cerebellitis.
Eur J Paediatr Neurol
November 2023
Background: Acute cerebellitis (AC) in children and adolescents is an inflammatory disease of the cerebellum due to viral or bacterial infections but also autoimmune-mediated processes.
Objective: To investigate the frequency of autoantibodies in serum and CSF as well as the neuroradiological features in children with AC.
Material And Methods: Children presenting with symptoms suggestive of AC defined as acute/subacute onset of cerebellar symptoms and MRI evidence of cerebellar inflammation or additional CSF pleocytosis, positive oligoclonal bands (OCBs), and/or presence of autoantibodies in case of negative cerebellar MRI.
Background: Dysglycaemia increases the risk of myocardial infarction and subsequent recurrent cardiovascular events. However, the role of dysglycaemia in ischemia/reperfusion injury with development of irreversible myocardial tissue alterations remains poorly understood. In this study we aimed to investigate the association of ongoing dysglycaemia with persistence of infarct core iron and their longitudinal changes over time in patients undergoing primary percutaneous coronary intervention (PCI) for acute ST-segment elevation myocardial infarction (STEMI).
View Article and Find Full Text PDFSerum Biomarker Profiles Discriminate AQP4 Seropositive and Double Seronegative Neuromyelitis Optica Spectrum Disorder.
Neurol Neuroimmunol Neuroinflamm
January 2024
Background And Objectives: Glial fibrillary acidic protein (GFAP) and neurofilament light chain (NfL) serum levels are useful to define disease activity in different neurologic conditions. These biomarkers are increased in patients with aquaporin-4 antibody-positive NMOSD (AQP4+NMOSD) during clinical attacks suggesting a concomitant axonal and glial damage. However, there are contradictory results in double seronegative NMOSD (DS-NMOSD).
View Article and Find Full Text PDFArticle Synopsis
- MOGAD is a rare autoimmune disease that can resemble multiple sclerosis (MS), making diagnosis challenging due to variable antibody assay results and low-positive titers.
- The study analyzed CSF parameters from 30 MOGAD patients and 189 MS patients to identify differences that could aid in distinguishing between the two conditions.
- Results showed that MOGAD patients often had a higher white cell count and specific CSF characteristics compared to MS patients, with significant indicators like a Q ratio greater than 10×10 and the absence of CSF-restricted OCB suggesting a diagnosis of MOGAD.
Background: Standard modifiable cardiovascular risk factors (SMuRFs) are well-established players in the pathogenesis of ST-elevation myocardial infarction (STEMI). However, in a significant proportion of STEMI patients, no SMuRFs can be identified, and the outcomes of this subgroup are not well described.
Objectives: To assess the infarct characteristics at myocardial-tissue level and subsequent clinical outcomes in SMuRF-less STEMIs.