Publications by authors named "Reinand Thompson"
Article Synopsis
- Immunology and microbiology research has advanced our understanding of immune responses, disease development, and treatment options, highlighting the importance of these fields in global healthcare.
- Key innovations include the use of bacterial immunoglobulin-binding proteins in diagnostics and a focus on antimicrobial resistance, particularly extended-spectrum beta-lactamases (ESBLs), which inform treatment strategies.
- Clinical research has improved management of immune-related conditions and vaccine development against diseases like tuberculosis and HIV, leading to better patient outcomes and collaborative global efforts in health care.
Systemic lupus erythematosus (SLE) is an idiopathic chronic autoimmune disease that can affect any organ in the body, including the neurological system. Multiple factors, such as environmental (infections), genetic (many HLA alleles including DR2 and DR3, and genes including C4), and immunological influences on self-antigens, such as nuclear antigens, lead to the formation of multiple autoantibodies that cause deleterious damage to bodily tissues and organs. The production of autoantibodies, such as anti-dsDNA, anti-SS(A), anti-SS(B), anti-Smith, and anti-neuronal DNA are characteristic features of this disease.
View Article and Find Full Text PDFChronic granulomatous disease (CGD) is a primary immunodeficiency caused by a defect in the phagocytic function of the innate immune system owing to mutations in genes encoding the five subunits of the nicotinamide adenine dinucleotide phosphatase (NADPH) oxidase enzyme complex. This review aimed to provide a comprehensive approach to the pathogens associated with chronic granulomatous disease (CGD) and its management. Patients with CGD, often children, have recurrent life-threatening infections and may develop infectious or inflammatory complications.
View Article and Find Full Text PDFObjective: To assess colonization of [group B streptococcus (GBS)], and delineate capsular serotype distribution and antibiotic susceptibility profiles among pregnant women in Trinidad and Tobago.
Methods: Vaginal swabs were collected from 248 pregnant women attending antenatal clinics in northern Trinidad, and processed using standard microbiological laboratory tests to confirm GBS. Polymerase chain reaction detected and serotype genes.