Publications by authors named "Reinaldo Dos Santos Theodoro"
Article Synopsis
- Xylene is a toxic volatile organic compound used in industries, making the development of sensitive gas sensors for its detection crucial for health and environmental safety.! -
- The researchers created two types of nickel oxide (NiO) composites—double-shell (NiO-YDS) and triple-shell (NiO-YTS)—using a microwave-assisted method, and tested their ability to detect various substances, with a focus on xylene.! -
- The NiO-YTS sensor outperformed the NiO-YDS sensor, showing a high sensitivity of 217.5% for xylene, with excellent stability and quick response times, indicating its potential for improved gas sensing applications.!
The emergence and spread of multidrug-resistant (MDR) enterococci and other Gram-positive bacteria represents a severe problem due to the lack of effective therapeutic alternatives. Natural products have long been an important source of new antibacterial scaffolds and can play a key role in the current antibiotic crisis. Enterococci are predominantly non-pathogenic gastrointestinal commensal bacteria, but among them, Enterococcus faecalis and Enterococcus faecium represent the species that account for most clinically relevant infections.
View Article and Find Full Text PDFObjectives: Periodontitis is a pathology resulting from complex interaction of microorganisms in the dental biofilm with the host's immune system. Increased use of antibiotics associated with their inappropriate use has increased resistance levels in anaerobic bacteria. Therefore, identifying new antimicrobial compounds, such as chalcones, is urgent.
View Article and Find Full Text PDFArticle Synopsis
- Isobavachalcone (IBC) is a natural compound that shows strong antibacterial effects, particularly against Methicillin-Susceptible and Methicillin-Resistant Staphylococcus aureus (MSSA and MRSA).
- It was effective at low concentrations (MIC of 1.56 µg/mL for MSSA and 3.12 µg/mL for MRSA) but ineffective against Gram-negative bacteria.
- IBC also inhibited biofilm formation and did not harm human skin cells, indicating its potential for use as an antibacterial drug and in medical applications.
Antibiofilm and cytotoxic effect of 3,3'-dihydroxycurcumin (DHC) as photosensitizer agent in antimicrobial photodynamic therapy for endodontic purposes.
Photodiagnosis Photodyn Ther
December 2021
Background: Curcuminoids have been designed not only to improve chemical and metabolic stability of curcumin (CUR), but also to increase its antimicrobial activity, without effecting its ability as photosensitizer agent in antimicrobial photodynamic therapy (aPDT) with light emitting diode (LED). This study evaluated the antimicrobial and antibiofilm action of curcumin analog DHC (or 3,3'-dihydroxycurcumin), submitted or not to LED irradiation, on microorganisms of endodontic importance and its influence on fibroblasts viability.
Methods: DHC was synthetized by modified Pablon's methodology and the experiments were conducted under irradiation or not with indium gallium nitride-based LED (440-480nm, 100 mW/cm, 0.