Publications by authors named "Reinaldo Barros Geraldo"
Article Synopsis
- This study focuses on creating and testing 6-aminated 1,4-benzoquinones (6-AQs) for their ability to combat seven resistant pathogens.
- The 6-AQs were synthesized using a reaction between bromoquinone and substituted anilines, and their antimicrobial effectiveness was analyzed, revealing minimum inhibitory concentrations between 16 to 128 μg/ml.
- Notably, two derivatives showed effectiveness against methicillin-resistant strains, showcasing both bacteriostatic and bactericidal properties and suggesting these compounds as potential new treatments.
Recently, the well-known geographically wide distribution of sporotrichosis in Brazil, combined with the difficulties of effective domestic feline treatment, has emphasized the pressing need for new therapeutic alternatives. This work considers a range of synthetic derivatives as potential antifungals against isolated from cats from the hyperendemic Brazilian region. Six isolates from the sporotrichotic lesions of itraconazole responsive or non-responsive domestic cats were studied.
View Article and Find Full Text PDFAntibiofilm effects of N,O-acetals derived from 2-amino-1,4-naphthoquinone are associated with downregulation of important global virulence regulators in methicillin-resistant Staphylococcus aureus.
Sci Rep
November 2020
Article Synopsis
- Antimicrobial resistance poses a significant challenge despite available antibiotics, leading to the urgent need for new drug development.
- This study focused on synthetic N,O-acetals from 2-amino-1,4-naphthoquinone and their effectiveness against methicillin-resistant Staphylococcus aureus (MRSA), particularly highlighting the notable impact of compound 7b on biofilm formation.
- Compound 7b was found to inhibit key virulence genes and showed potential to eliminate persistent bacterial cells, making it a promising candidate for future antimicrobial research aimed at treating chronic infections associated with biofilm.
Schistosomiasis is one of the world's major public health problems, and its treatment is widely dependent on praziquantel (PZQ), the only available drug. Schistosoma mansoni ATP diphosphohydrolases are ecto-enzymes localized on the external tegumental surface of S. mansoni and considered an important target for action of new drugs.
View Article and Find Full Text PDFPlatelets are cytoplasmatic fragments from bone marrow megakaryocytes present in blood. In this work, we review the basis of platelet mechanisms, their participation in syndromes and in arterial thrombosis, and their potential as a target for designing new antithrombotic agents. The option of new biotechnological sources is also explored.
View Article and Find Full Text PDFTritrichomonas foetus is a protist that causes bovine trichomoniasis and presents a well-developed Golgi. There are very few studies concerning the Golgi in trichomonads. In this work, monoclonal antibodies were raised against Golgi of T.
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