Publications by authors named "Reina Lansigan"

Article Synopsis
  • The study aimed to investigate how certain genetic factors related to obesity influence children's brain responses to food advertisements after eating.* -
  • Researchers analyzed fMRI data from 151 children aged 9-12 and found that a specific genetic variant (rs9939609) was associated with increased brain activity in the lateral hypothalamus in response to food cues, although this result wasn't significant after correcting for multiple comparisons.* -
  • The overall conclusion suggests that children with a genetic predisposition to obesity may exhibit stronger brain reward responses to food cues, which might lead to overeating.*
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Objective: The objective of this study is to evaluate obesity-related genetic factors in relation to excess consumption and assess if food cues modify associations.

Methods: Children (9-12 years) completed a randomized crossover experiment. During two visits, children ate a preload and then snacks ad libitum while watching television, embedded with food or non-food advertisements to assess eating in the absence of hunger (EAH).

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Background/objectives: Obesity polygenic risk scores (PRS) explain substantial variation in body mass index (BMI), yet associations between PRSs and appetitive traits in children remain unclear. To better understand pathways leading to pediatric obesity, this study aimed to assess the association of obesity PRSs and appetitive traits.

Subjects/methods: This study included 248 unrelated children aged 9-12 years.

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Decreased behavioral regulation is hypothesized to be a risk factor for excess weight gain among children, possibly via reduced appetite-specific regulation. Little research has specifically focused on behavioral regulation and food cue responsiveness, a conditioned precursor to eating, at a young age. This study examined the association between behavioral regulation and external food cue responsiveness among preschool-age children and explored if a more structured parenting style moderated that association.

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Introduction: Food cues including food advertisements (ads) activate brain regions related to motivation and reward. These responses are known to correlate with eating behaviors and future weight gain. The objective of this study was to compare brain responses to food ads by different types of ad mediums, dynamic (video) and static (images), to better understand how medium type impacts food cue response.

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Purpose: To measure attention to food cues following a multitask or a sustained attention single task, and further, to examine the associations with current weight status and excess consumption.

Methods: Ninety-six 13-to 17-year-olds were fed a standardized meal and then had their attention to food cues measured following completion of a single sustained attention task, media multitask, or a passive viewing control task. Participants then completed an eating in the absence of hunger paradigm to measure their excess consumption.

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Objective: To assess distracted attention and performance on a computer task following completion of a sustained attention and acute media multitasking task among adolescents with varying self-reported usual media multitasking.

Methods: Ninety-six 13- to 17-year-olds played the video game Tetris following completion of a Go/No-go paradigm to measure sustained attention in the presence of distractors, an acute media multitasking, or a passive viewing condition. Adolescents completed the conditions on separate visits in randomized order.

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Objective: Attentional bias to food cues may be a risk factor for childhood obesity, yet there are few paradigms to measure such biases in young children. Therefore, the present work introduces an eye-tracking visual search task to measure attentional bias in young children.

Methods: Fifty-one 3-6-year-olds played a game to find a target cartoon character among food (experimental condition) or toy (control condition) distractors.

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Background: Conditioned eating in response to external food cues may contribute to obesity risk in young children.

Objectives: To develop a brief, parent-reported scale to measure external food cue responsiveness for preschool-age children.

Methods: Focus groups with parents of preschool-age children were conducted to create an initial pool of items reflecting children's behavioral responses to external food cues.

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Background: Excess screen media use is a robust predictor of childhood obesity. Understanding how household factors may affect children's screen use is needed to tailor effective intervention efforts. The preschool years are a critical time for obesity prevention, and while it is likely that greater household disorder influences preschool-aged children's screen use, data on that relationship are absent.

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Polymorphisms in the Fat Mass and Obesity Associated (FTO) gene are robustly associated with overweight and obesity among children, although the underlying mechanisms are poorly understood. We tested if appetitive traits partially mediated the association between FTO genotype and increased BMI among a sample of US preadolescents. Data were from 178 unrelated 9-10 year olds who participated in an experimental study between 2013 and 2015.

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Background: Preschoolers in the United States are heavily exposed to unhealthy food advertisements. Whether such exposure promotes cued eating has not been documented in this age group.

Methods: Randomized experiment among 60 children, aged 2 to 5 years, recruited in 2015-2016 from New Hampshire and Vermont.

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Background: Eating in the Absence of Hunger (EAH), or consuming highly palatable foods when satiated, is one behavioral pathway that may lead to childhood obesity. EAH is an objective, laboratory-based measure. A more comprehensive understanding of potential determinants of EAH could inform childhood obesity programs outside of a laboratory setting.

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