Publications by authors named "Reina Fujii"
Article Synopsis
- Progestin inhibits the growth of both normal and cancerous endometrial cells mainly through the progesterone receptor subtype PRB, rather than PRA.
- *The study identified that the gene FOXO1 is up-regulated by progestin in a PRB-dependent way, and it acts as an upstream regulator of IGFBP-1, which is also induced by progestin.
- *The findings suggest that the FOXO1/IGFBP-1 pathway is crucial for the growth-inhibitory effects of progestin in endometrial epithelial cells, highlighting potential therapeutic applications.*
