Publications by authors named "Reiko Okamura"
Article Synopsis
- * Imaging tests revealed multiple brain and lung nodules, and blood tests indicated symptoms consistent with hemophagocytic syndrome.
- * A bone marrow examination confirmed the presence of Toxoplasma gondii, leading to treatment; however, the patient ultimately developed multiple organ failure and died shortly after admission.
Article Synopsis
- Most follicular lymphomas (FLs) are typically slow-progressing with good outcomes, but some patients face disease worsening within 24 months (POD24), leading to poorer results.
- This study aimed to identify predictive risk factors for POD24 and analyze the microenvironment characteristics in FL patients experiencing POD24.
- The research found that higher Ki-67 expression significantly correlates with POD24 events, and those patients also showed a decrease in certain immune cells, suggesting implications for targeted treatment approaches.
Article Synopsis
- This study compares two chemotherapy regimens used in patients undergoing umbilical cord blood transplantation: Flu/Mel/Bu2 (lower busulfan dose) and Flu/Mel/Bu4 (higher busulfan dose).
- Researchers analyzed data from 87 adult patients to see if there were differences in nonrelapse mortality, relapse rates, progression-free survival, and overall survival between the two regimens.
- The results showed no significant differences in outcomes, suggesting that the Flu/Mel/Bu2 regimen is a safe and effective option, particularly for older patients.
Article Synopsis
- Diffuse large B-cell lymphoma (DLBCL) shows varied clinical and genetic characteristics, but differences between primary extranodal and nodal DLBCL, especially involving double-expressor lymphoma (DEL), remain unclear.
- The study analyzed 61 primary extranodal and 128 nodal DLBCL cases, finding that nodal DLBCL had higher BCL2 expression, while DEL was linked to poor outcomes in extranodal cases.
- Results indicated that DEL significantly impacted progression-free and overall survival in primary extranodal DLBCL patients, establishing it as a crucial adverse prognostic factor.
Article Synopsis
- * Researchers examined 91 patients with blood cancers and found that those with certain FOXP3 genotypes (FOXP3-3279C/A or FOXP3-3279A/A) are at a significantly higher risk for severe chronic graft-versus-host disease (cGVHD).
- * The findings suggest that this genetic marker could help predict which patients are more likely to experience severe cGVHD after transplantation, aiding in better patient management.
Immune checkpoint inhibitor (ICI)-induced thrombocytopenias are rare immune-related adverse events (irAE), but ICI-related thrombotic thrombocytopenic purpura (TTP) is extremely rare. A 79-year-old woman with non-small cell lung cancer received maintenance therapy with the anti-human PD-L1 monoclonal antibody durvalumab. Four weeks after the last infusion, she developed overt TTP.
View Article and Find Full Text PDFA 75-year-old man who had lymphadenopathy was admitted to our hospital. Histopathological examination of cervical lymph node biopsy specimens showed diffuse proliferation of lymphoma cells with large nuclei. In immunohistochemistry, the lymphoma cells were positive for CD5, CD10, CD20, BCL2, BCL6, and MYC.
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