Publications by authors named "Reiko M Nakamura"
J Leukoc Biol
December 2005
Article Synopsis
- Hosts exposed to low doses of mycobacteria develop Th1 immunity, while higher doses trigger a shift to Th2 immunity due to the influence of Prostaglandin E2 (PGE2).
- The study observed that macrophages in the spleen release PGE2 in a dose-dependent manner when treated with heat-killed Mycobacterium bovis BCG, influencing cytokine production and immune response markers.
- Mice given higher doses showed increased Th2-related antibodies and cytokines, suggesting that PGE2 and PGHS-2 are key mediators in the transition from Th1 to Th2 responses in the immune system.
