Selective remodeling of rabbit frontal cortex: relationship between 5-HT2A receptor density and associative learning.

Rationale: Associative learning during classical trace eyeblink conditioning has been shown to be regulated by serotonin 5-HT(2A )receptors and to be critically dependent on the integrity of frontal cortex. Chronic administration of 5-HT(2A) ligands has been shown to produce a selective up- or down-regulation of 5-HT(2A) receptors in frontal cortex.

Objectives: We examined whether alterations in 5-HT(2A) receptor density had a functional significance with respect to associative learning.