Publications by authors named "Reiji Nakano"
Article Synopsis
- The study investigates the clinical features of patients with cryopyrin-associated periodic syndrome (CAPS) in Japan and assesses the effectiveness and safety of the IL-1 inhibitor canakinumab in treating these patients.
- Out of 101 patients analyzed, a significant majority achieved complete remission with canakinumab, but 23.7% did not respond, experiencing serious complications including deaths and organ damage.
- The research highlights the importance of early intervention and suggests that combining canakinumab with other therapies can be beneficial for those who don't adequately respond to canakinumab alone.
Article Synopsis
- Very low birth weight infants (VLBWIs) with esophageal atresia (EA) face significant risks for poor outcomes, including survival and neurodevelopmental issues.
- A study analyzed 103 VLBWIs with EA and found that 68% were discharged from the NICU, but survival rates decreased with lower birth weights and the presence of associated anomalies.
- Neurodevelopmental impairment (NDI) affected about 35% of patients at a 3-year follow-up, also increasing with lower birth weight, indicating that these infants need careful monitoring even after NICU discharge.
Purpose: Surgical intestinal disorders (SID), such as necrotizing enterocolitis (NEC), focal intestinal perforation (FIP), and meconium-related ileus (MRI), are serious morbidities in extremely low birth weight (ELBW, birth weight <1000 g) infants. From 2010, we performed enteral antifungal prophylaxis (EAP) in ELBWI to prevent for SID. The aim of this study was to identify disease-specific risk factors and to evaluate the efficacy of prevention for SID in ELBW infants.
View Article and Find Full Text PDFIn this study, we used "RAPIRUN(®)Streptococcus pneumoniae HS (otitis media/sinusitis) (RAPIRUN-HS)," a rapid S. pneumoniae antigen detection kit, to investigate methods for detecting S. pneumoniae antigens in blood of 32 bacterial pneumonia patients.
View Article and Find Full Text PDFA 66-year-old man was transferred to our hospital on November 2010 owing to a diagnosis of miliary tuberculosis. Treatment was initially started with INH, RFP, PZA, and EB. However, PZA and EB were discontinued because of their adverse effects.
View Article and Find Full Text PDFIntroduction: We report a case of a 1.8-kg infant who had laparoscopic Toupet fundoplication (LTF) using the AirSeal Intelligent Flow System and Anchor Port (AP).
Materials And Surgical Technique: Our case had severe gastroesophageal reflux in association with genetic and cardiac anomalies.
We describe herein a case of unilateral pulmonary agenesis (PA) with oesophageal atresia (EA)/tracheoesophageal fistula (TEF) that was diagnosed prenatally and repaired by esophagoesophagostomy with stable postoperative course. The patient was born at 34 weeks gestation, after ultrasonography at 22 weeks gestation showed possible right-sided diaphragmatic eventration or PA and EA was subsequently suspected due to hydramnios. The initial X-ray showed mediastinal shift to the right, and coil up sign of the nasogastric tube, without intracardiac anomaly.
View Article and Find Full Text PDFPurpose: The internal anal sphincter (IAS) plays an important role in the pathophysiology of constipation and incontinence. We hypothesized that functional bowel obstruction in premature infants is because of a poorly developed IAS. We investigated the neuromuscular development of IAS in fetal, newborn, and adolescent pigs.
View Article and Find Full Text PDFPharmacokinetics, clinical efficacy and safety of teicoplanin (TEIC) were evaluated in pediatric and neonate patients with MRSA sepsis in the dosages approved in overseas. The administrated dose for pediatrics patients was 10 mg/kg once at hour 0, 12 and 24, followed by every 24 hours intervals. In neonates patients, first dose was 16 mg/kg, then 8 mg/kg every 24 hours intervals.
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