Publications by authors named "Reijane A de Assis"
Extramedullary haematopoiesis in patients with thalassemia: a cross-sectional description of its prevalence, clinical features and survival.
Hematol Transfus Cell Ther
November 2024
Introduction: Despite knowledge advances on extramedullary haematopoiesis (EMH) in thalassemic patients, the real picture remains an open issue.
Objectives: To assess EMH prevalence in patients with thalassemia major (TM) and intermedia (TI), to describe magnetic resonance imaging (MRI) findings and to explore clinical risk factors.
Methods: In this cross-sectional study, images and clinical records of 184 consecutive patients with thalassemia who underwent T2* MRI between 2004 and 2011 were reviewed.
Cardiac iron overload evaluation in thalassaemic patients using T2* magnetic resonance imaging following chelation therapy: a multicentre cross-sectional study.
Hematol Transfus Cell Ther
May 2021
Article Synopsis
- The study investigates the effectiveness of MRI T2* in measuring iron levels in thalassaemic patients' organs, focusing on the heart, liver, and pancreas during chelation therapy.
- A total of 136 major thalassaemic patients, with a median age of 18, were analyzed, revealing that iron overload primarily affects the liver (99%) and the pancreas (74%), while the heart is less impacted (36%).
- Results showed a significant reduction in heart iron levels after 1.2 years of therapy, and a strong predictive model for assessing cardiac siderosis was developed based on MRI and ferritin levels.
Purpose: To assess the correlation between MRI findings of the pancreas with those of the heart and liver in patients with beta thalassemia; to compare the pancreas T2* MRI results with glucose and ferritin levels and labile plasma iron (LPI).
Materials And Methods: We retrospectively evaluated chronically transfused patients, testing glucose with enzymatic tests, serum ferritin with chemiluminescence, LPI with cellular fluorescence, and T2* MRI to assess iron content in the heart, liver, and pancreas. MRI results were compared with one another and with serum glucose, ferritin, and LPI.