Early-Age Evolution of Strength, Stiffness, and Non-Aging Creep of Concretes: Experimental Characterization and Correlation Analysis.

Six different concretes are characterized during material ages between 1 and 28 days. Standard tests regarding strength and stiffness are performed 1, 3, 7, 14, and 28 days after production. Innovative three-minute-long creep tests are repeated hourly during material ages between one and seven days.

Consistent quasistatic and acoustic elasticity determination of poly-L-lactide-based rapid-prototyped tissue engineering scaffolds.

This paper is concerned with reliable and physically sound elasticity determination of rapid-prototyped tissue engineering scaffolds made of poly-L-lactide (PLLA), with and without small portions of tricalcium phosphate (TCP) inclusions. At the level of overall scaffolds, that is, that of several millimeters, multiple uniaxial loading-unloading (quasistatic) tests were performed, giving access to the scaffolds' Young's moduli, through stress-strain characteristics during unloading. In addition, acoustic tests with 0.

Superiority of bridging techniques with medial fixation on initial strength.

Purpose: The purpose of our study was to evaluate the initial fixation strength of bridging techniques compared to other suture techniques for rotator cuff repair using a biomechanical animal model, which incorporated pretesting of intact tendons.

Methods: Seventy-six fresh bovine shoulders were used for testing seven suture configurations including simple suture (SS), mattress suture (MS), Mason-Allen (MA), modified double row (mDR), SpeedBridge (SpB), SpeedBridge with medial fixation (mSpB), and double-mattress SutureBridge (dmSuB) techniques. Cyclic loading was performed with all intact bone-tendon complex before (pretest) and after repair of the tendon (main test) at the level of 10 and 180 N at 100 Hz with displacement-controlled ramps of ± 33 mm/s.

Biomechanical criterion for selecting cancellous bone screws: arthrodesis in the hindfoot.

The aim of the paper was to compare primary biomechanical stability of different arthrodesis screws (7.3 mm AO screw with and without washer, 6.5 mm Herbert screw and 6.

Biomechanical analysis of fracture healing in guinea-pigs.

To validate the hypothesis that healing of fractures can be accelerated by oral administered L-arginine a guinea-pig model was chosen. A diaphyseal defect fracture was established in the right femur of each of the 32 small animals and stabilized. According to randomization groups the oral administration was realized (2 or 4 weeks medication / solvent).

In-vitro comparison of biomechanical efficiency of three cannulated screws for arthrodesis of the hindfoot.

Background: Sufficient inter-fragmentary compression is helpful to achieve successful bony fusion in hindfoot arthrodesis using internal fixation by screws. Beside bone quality, the design of a screw influences inter-fragmentary compression. Compressive force is achievable for any kind of screw system; however, the primary deformation of the bone is different for the different screw systems.

The influence of oral L-arginine on fracture healing: an animal study.

Background: The known biological activities of nitric oxide suggest a role in bone healing. We hypothesized that L-arginine, a source of nitric oxide, expedites the healing process of stabilized diaphyseal defects.

Type Of Study: Prospective blinded animal study.

Accuracy of pressure and flow capacities of four arthroscopic fluid management systems.

Purpose: The present study was conducted to evaluate 4 different fluid delivery systems: Arthrex AR-6450, Stryker 1.5L High Flow Pump, Arthro FMS 4, and Acufex InteliJet. Their flow and pressure capacity, as specified by the manufacturer, and their accuracy, as measured in a standardized fashion, were compared with directly measured pressure values.

Alterations of biochemical and two-dimensional biomechanical properties of human skin in diabetes mellitus as compared to effects of in vitro non-enzymatic glycation.

Objective: The aim of this study was to evaluate whether multiaxial analysis of diabetes-specific biomechanical changes generated in vitro by non-enzymatic glycation of human skin samples from healthy subjects reflect the changes seen in skin from subjects with diabetes mellitus.

Design: Descriptive study.

Background: Non-enzymatic glycation of skin in vitro causes an increased stiffness comparable to in vivo changes seen in diabetic patients.

Mechanical properties of a rat patellar tendon stress-shielded in situ.

The effects of stress deprivation on the mechanical properties of the patellar tendon (PT) were studied using 14 albino rats. The PT was stress-shielded with cerclages on one side, while the contralateral patellar tendon served as a sham-operated control. After 10 weeks, paired load-strain as well as load-relaxation experiments were performed (11 and 3 specimen pairs, respectively).

Comparison of palmar aponeuroses from individuals with diabetes mellitus and Dupuytren's contracture.

It is well known that Dupuytren's contracture is often associated with diabetes mellitus. Palmar fascia from individuals with diabetes mellitus and/or Dupuytren's contracture as well as controls were subjected to differential scanning calorimetry, biomechanical and biochemical analysis. The collagen denaturation temperature of the palmar aponeurosis from individuals with diabetes mellitus in the presence (71.

Two-dimensional stress-relaxation behavior of human skin as influenced by non-enzymatic glycation and the inhibitory agent aminoguanidine.

In order to simulate the in vivo stress alterations of diabetic skin in an in vitro model, we examined the viscoelastic properties of long-term glycated human skin samples. Since skin is subjected to biaxial tension, we used two-dimensional multiaxial testing which better reflects the in vivo situation than the uniaxial testing mode. For native skin samples from the abdominal region we found a direction-dependent elastic stress strain behavior.

Twisting of patellar tendon grafts does not reduce their mechanical properties.

The purpose of this study was to investigate whether the twisting of a patellar tendon (PT) graft improves or reduces its mechanical properties. Twenty-seven pairs of 10 mm cadaveric PT grafts were tested at a strain rate of 10% min(-1). For each pair, the left specimen served as an unmanipulated control while the right specimen was either left untwisted, twisted + 90 degrees, or twisted - 90 degrees.

Biomechanical stability of abductor pollicis longus muscles with variable numbers of tendinous insertions.

Background: In the course of a study of different variants of the tendon of the abductor pollicis longus (APL) muscle, the unusual finding of a tendon with six subdivisions was observed in the first compartment. Using this preparation and others with various numbers of tendons (2, 3, 4, and 6), we intended to establish whether the multitendoned muscles increased the strength of the thumb.

Methods: Fifty-two upper extremities were examined with attention to the tendons of the APL muscle.

Comparison of normal and in vitro aging by non-enzymatic glycation as verified by differential scanning calorimetry.

The biomechanical parameters of rat tail tendons (RTTs) from 35-, 64-, 180- and 900-day-old animals, corresponding to the early maturation phase, the mature and the senescent state were determined. The increase of maximum stiffness, ultimate stress and the elastic fraction of stress was most pronounced in the maturation phase. Differential scanning calorimetry (DSC) experiments were performed showing an almost linear increase of the collagen denaturation temperature in the age range 35-139 days.

Effects of aminoguanidine on adhesion molecule expression of human endothelial cells.

The effect of aminoguanidine (AG) on the expression of adhesion molecules on nonactivated human umbilical vein endothelial cells (HUVEC) was investigated in vitro. Nonactivated HUVEC cultivated on long-term glycated fibronectin (FN) as compared to native FN showed a significant upregulation of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1) and CD31 which could be further promoted by long-term glycated bovine serum albumin. AG, at a concentration of 0.

Comparison of the effect of different inhibitors of the non-enzymatic glycation of rat tail tendons and bovine serum albumin.

The biomechanical and biochemical properties of collagen are changed by non-enzymatic glycation culminating in increased cross-linking. We have previously shown that dibasic amino acids such as L-arginine inhibit in vitro the non-enzymatic glycation of soluble proteins and insoluble connective tissue macromolecules. In the present in vitro study we obtained evidence that the nucleophilic hydrazine derivative aminoguanidine and the non-steroidal anti-rheumatic drug ibuprofen inhibit the formation of fluorescent advanced glycation end products (AGEs) to a comparable extent, while arginine is ineffective as a consequence of its tendency to form AGEs itself.

On the orthogonal anisotropy of human skin as a function of anatomical region.

Skin samples were obtained from 8 anatomical sites of 6 human deceased at ages ranging from 30 to 80 years 24 hours post mortem. As shown by biochemical analysis the collagen content varied between 71% and 78% depending on the anatomical location of the skin samples. The content of collagen type III was in the range of 19.

Two-dimensional elastic properties of human skin in terms of an incremental model at the in vivo configuration.

The two-dimensional biomechanical behaviour and the collagen content of human skin samples from different anatomical sites was examined. The axes of minimum and maximum shrinkage after excision were determined and correlated with the 'Langer' cleavage lines. Test equipment was developed to restore the original geometry and to measure the loads acting perpendicular to the circumference of the skin specimens.

Mechanical properties of peripheral nerves.

Peripheral nerve trunks are viscoelastic tissues with unique mechanical characteristics. Tensile strength, which includes elastic limit and mechanical failure, concerns surgeons. This study shows that measurements of the load necessary to achieve certain elongations on specimens outside the body do not correspond with in situ measurements.

Biomechanical properties of normal tendons, normal palmar aponeuroses and palmar aponeuroses from patients with Dupuytren's disease subjected to elastase and chondroitinase treatment.

Normal tendons, normal palmar aponeuroses and specimens from patients with Dupuytren's disease, namely apparently normal palmar aponeuroses and contracture bands were subjected to elastase and chondroitinase ABC digestion. Maximum Young's modulus, normalized hysteresis loop and residual elongation were determined before and after enzyme treatment. In normal tendons, normal and apparently normal palmar aponeuroses both normalized hysteresis loop and residual elongation increased significantly after elastase treatment, whereas the stiffness decreased.

Biomechanical properties of normal tendons, normal palmar aponeuroses, and tissues from patients with Dupuytren's disease subjected to elastase and chondroitinase treatment.

Normal tendons, normal palmar aponeuroses and palmar aponeuroses from patients with Dupuytren's disease were subjected to elastase or chondroitinase treatment. Young's modulus was derived from the linear portion of stress-strain graph. It showed the lowest value for the apparently normal palmar aponeuroses and the highest value for tendon samples.

The influence of L-arginine on biomechanical parameters of native and nonenzymatically glycated rat tail tendons.

Rat tail tendons from animals of an age range from 35 days to 900 days were glycated using different glucose concentrations. After nonenzymatic glycation the biomechanical properties of tendons from young rats approached that of old tendons. In tendons from old animals the glucose incorporation was significantly lower than in young rat tail tendons.

Mechanical changes in rat tail tendons induced by dibasic amino acids as a function of age.

Rat tail tendons from 54-day-old and 900-day-old animals were incubated with different concentrations of the dibasic amino acids, lysine and arginine. We observed a significant incorporation of these amino acids into the tendons. Uniaxial tension tests and relaxation experiments were performed at strain levels within the linear portion of the stress-strain relationship.

Measurement of stress-strain relationship and stress relaxation in various synthetic ligaments.

In an experimental study various synthetic augmentation devices for knee ligament surgery were tested in a servo-mechanical universal tensile testing machine under uniaxial loading. Two tests were done to elucidate the mechanical behaviour: stress relaxation and stress-strain relationship. Regarding the point of failure or rupture, the strongest ligament was the Trevira at 1800 N, followed by the 8-mm-wide Kennedy LAD at 1720 N.