The transformative journey of community health workers in implementing a lifestyle intervention in Brazil: A qualitative study.

Introduction: Community health workers (CHWs) stand as critical frontline agents within the Brazilian healthcare system. In this qualitative study, we examined the impact of a community-based behavioral change intervention spearheaded by CHWs.

Methods: The intervention focused on promoting healthy behaviors - physical activity, nutrition, and emotional well-being - among individuals aged 50 and older living in a rural community in Brazil.

Gender-dependent effect of physical activity on the risk of incident multimorbidity during the COVID-19 pandemic: Findings from the PAMPA cohort, Brazil.

Objectives: We aimed to investigate the association between physical activity (PA) and the risk of incident multimorbidity in adults from southern Brazil during the COVID-19 pandemic.

Study Design: Prospective Study.

Methods: We analyzed data from the Prospective Study about Physical and Mental Health (PAMPA) cohort, a longitudinal study of adults living in southern Brazil.

Studies of physical activity and COVID-19 during the pandemic: an updated scoping review.

Background: This review is an update of the previous study aiming to identify the available evidence related to physical activity (PA) in the context of the coronavirus disease (COVID-19) pandemic.

Methods: We searched 6 databases (PubMed, Embase, SPORTDiscus, Scopus, Web of Science, and CINAHL) in April 2024. Medical subject headings and keywords related to PA and COVID-19 were combined to conduct the online search, which covered the period from July 2020 to April 2024.

Reference Information Model and Interoperable Architecture for Digital Health Twins: A Position Paper.

Digital Health Twins (DHTs) hold immense potential to revolutionize healthcare by providing personalized virtual models of individual patients and their health conditions. This position paper discusses about the needs to overcoming the challenges in standardization and information models for data integration, collection, and visualization for realizing the full potential with digital twin technology. By addressing these challenges, digital health twins can enable better decision-making, enhance patient care, and contribute to the advancement of personalized healthcare solutions.

Association between food insecurity and long COVID in adults from southern Brazil: findings of the PAMPA cohort.

Background: Social and economic factors, such as food insecurity, contribute to long coronavirus disease (COVID). During the pandemic, a significant rise in food insecurity was observed, both in Brazil and worldwide. We aimed to investigate the association between food insecurity and long COVID in Brazilian adults.

Dissemination of extensively drug-resistant NDM-producing in Europe linked to patients transferred from Ukraine, March 2022 to March 2023.

BackgroundThe war in Ukraine led to migration of Ukrainian people. Early 2022, several European national surveillance systems detected multidrug-resistant (MDR) bacteria related to Ukrainian patients.AimTo investigate the genomic epidemiology of New Delhi metallo-β-lactamase (NDM)-producing from Ukrainian patients among European countries.

Longitudinal impact of leisure-time physical activity on pain intensity and daily activity limitation in people with low back pain. Findings from the PAMPA cohort.

Objective: We aimed to prospectively evaluate the association between leisure-time physical activity and outcomes related to low back pain (LBP), such as pain intensity and daily activity limitation.

Methods: We analyzed data from the PAMPA (Prospective Study about Mental and Physical Health) cohort, a longitudinal study with adults residing in Southern Brazil. Participants answered an online-based, self-administered questionnaire.

[Arthritis and osteomyelitis in childhood and adolescence-Bacterial and nonbacterial].

Bacterial arthritis and osteomyelitis are usually acute diseases, which in this way differ from the often insidious course of nonbacterial osteomyelitis; however, there is often an overlap both in less acute courses of bacterial illnesses and also in nonbacterial osteitis. The overlapping clinical phenomena can be explained by similar pathophysiological processes. In bacteria-related illnesses the identification of the pathogen and empirical or targeted anti-infectious treatment are prioritized, whereas no triggering agent is known for nonbacterial diseases.

Ladostigil Reduces the Adenoside Triphosphate/Lipopolysaccharide-Induced Secretion of Pro-Inflammatory Cytokines from Microglia and Modulate-Immune Regulators, TNFAIP3, and EGR1.

Treatment of aging rats for 6 months with ladostigil (1 mg/kg/day) prevented a decline in recognition and spatial memory and suppressed the overexpression of gene-encoding pro-inflammatory cytokines, TNFα, IL1β, and IL6 in the brain and microglial cultures. Primary cultures of mouse microglia stimulated by lipopolysaccharides (LPS, 0.75 µg/mL) and benzoyl ATPs (BzATP) were used to determine the concentration of ladostigil that reduces the secretion of these cytokine proteins.

Prolonged carriage of OXA-244-carbapenemase-producing Escherichia coli complicates epidemiological investigations.

The rapid increase of OXA-244-producing Escherichia coli, predominantly driven by genetically clustered isolates of sequence type (ST)38, has been observed in at least nine European countries, including Germany. However, the reasons for the spread of OXA-244-producing E. coli remain unclear.

Deletion of CD47 from Schwann cells and macrophages hastens myelin disruption/dismantling and scavenging in Schwann cells and augments myelin debris phagocytosis in macrophages.

Background: Myelin that surrounds axons breaks in trauma and disease; e.g., peripheral nerve and spinal cord injuries (PNI and SCI) and multiple sclerosis (MS).

Digital Technology Use and Adolescent Mental Health Before and During the COVID-19 Pandemic: The Roles of Internet Addiction and Digital Competence.

This study examined whether Internet addiction (IA) and digital competence (DC) mediated the association between digital technology use and mental health problems in adolescents before and during the COVID-19 pandemic, when digital device use increased dramatically. Repeated cross-sectional data from a 3-year cross-cohort study adopting stratified random sampling were analyzed. In 2019, 569 adolescents (female = 312) from 14 secondary schools completed a DC assessment and an online survey on their digital technology use, IA, and mental health.

Failure of scabies treatment: a systematic review and meta-analysis.

Background: Treatment failure is considered to be an important factor in relation to the increase in scabies incidence over the last decade. However, the regional and temporal differences, in addition to the predictors of therapy failure, are unclear.

Objectives: We aimed to conduct a systematic review of the prevalence of treatment failure in patients with scabies and investigation of associated factors.

Coordinated Transcriptional Waves Define the Inflammatory Response of Primary Microglial Culture.

The primary role of microglia is to maintain homeostasis by effectively responding to various disturbances. Activation of transcriptional programs determines the microglia's response to external stimuli. In this study, we stimulated murine neonatal microglial cells with benzoyl ATP (bzATP) and lipopolysaccharide (LPS), and monitored their ability to release pro-inflammatory cytokines.

Physical activity and long COVID: findings from the Prospective Study About Mental and Physical Health in Adults cohort.

Objectives: The study investigated the longitudinal association between physical activity and the risk of long COVID in patients who recovered from COVID-19 infection.

Study Design: We analyzed longitudinal data of the Prospective Study About Mental and Physical Health cohort, a prospective cohort study with adults living in Southern Brazil.

Methods: Participants responded to an online, self-administered questionnaire in June 2020 (wave 1) and June 2022 (wave 4).

Absolute intensity thresholds for tri-axial wrist and waist accelerometer-measured movement behaviors in adults.

Aim: This study was aimed to: (1) compare raw triaxial acceleration data from GENEActiv (GA) and ActiGraph GT3X+ (AG) placed on the non-dominant wrist; (2) compare AG placed on the non-dominant and dominant wrist, and waist; (3) derive brand- and placement-specific absolute intensity thresholds for inactive and sedentary time, and physical activity intensity in adults.

Methods: Eighty-six adults (44 men; 34.6 ± 10.

Care seek behavior for low back pain in southern Brazil during the COVID-19 pandemic: a panel data analysis.

Background: During the COVID-19 pandemic, people with low back pain (LBP) might have avoided seeking care for their pain. We aimed to investigate how the COVID-19 pandemic has affected LBP care seeking behavior among adults.

Methods: Data from four assessments of the PAMPA cohort were analyzed.

Incidence of memory complaints during the COVID-19 pandemic in Southern Brazil: findings from PAMPA cohort.

Unlabelled: Population-level studies investigating the incidence of memory complaints during the COVID-19 pandemic are scarce.

Objective: This study aimed to examine the incidence of memory complaints over 15 months during the COVID-19 pandemic in adults from Southern Brazil.

Methods: Data from the PAMPA (Prospective Study about Mental and Physical Health in Adults) cohort, a longitudinal study with adults residing in Southern Brazil, were analyzed.