Publications by authors named "Rehan Sarfraz"
Article Synopsis
- Clostridial myonecrosis, or gas gangrene, is a serious and fast-moving bacterial infection that affects muscles and soft tissues, with around 1000 cases annually in the U.S. and even more in developing nations.
- It is primarily caused by the Clostridium bacteria, which thrive in low-oxygen environments from injuries, leading to two types: traumatic (from injuries) and spontaneous (in immunocompromised individuals).
- Symptoms include severe pain and swelling, rapid tissue death, and systemic effects if untreated; diagnosis relies on clinical assessments and imaging, while treatment consists of surgery, antibiotics, and possibly hyperbaric oxygen therapy.
Purpura fulminans (PF) is a disorder with multifactorial causes that lead to acute localize skin microvasculature thrombosis. PF can be classified as one of the manifestations of disseminated vascular coagulation (DIC). Although, there are three types of PF including hereditary (autosomal dominant) due to mutations in single nucleotide polymorphisms (PROC and PROS1) and serpin family C member 1 (SERPINC1) genes.
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