Patients with idiopathic pulmonary fibrosis with antibodies to heat shock protein 70 have poor prognoses.

Rationale: Diverse autoantibodies are present in most patients with idiopathic pulmonary fibrosis (IPF). We hypothesized that specific autoantibodies may associate with IPF manifestations.

Objectives: To identify clinically relevant, antigen-specific immune responses in patients with IPF.