Exploring pathogenic SNPs and estrogen receptor alpha interactions in breast cancer: An approach.

The estrogen receptor 1 gene () plays a crucial role in breast and mammary development in humans. Alterations such as gene amplification, genomic rearrangements, and missense mutations in the gene are reported to increase the risk of breast cancer in humans. The purpose of this study is to analyze the missense mutations and molecular modeling of , focusing on the pathogenic SNP H516N, for a better understanding of disease risk and future benefits for therapeutic benefits.