Exploring pathogenic SNPs and estrogen receptor alpha interactions in breast cancer: An approach.

The estrogen receptor 1 gene () plays a crucial role in breast and mammary development in humans. Alterations such as gene amplification, genomic rearrangements, and missense mutations in the gene are reported to increase the risk of breast cancer in humans. The purpose of this study is to analyze the missense mutations and molecular modeling of , focusing on the pathogenic SNP H516N, for a better understanding of disease risk and future benefits for therapeutic benefits.

Combination use of human menstrual blood stem cell- derived exosomes and hyperbaric oxygen therapy, synergistically promote recovery after spinal cord injury in rats.

Traumatic spinal cord injury (TSCI) is one of the catastrophic events in the nervous system that leads to the loss of sensory and motor function of the spinal cord at the site of injury. Considering that several factors such as apoptosis, inflammation, and oxidative stress play a role in the spread of damage caused by trauma, therefore, the treatment should also be based on multifactorial approaches. Currently, we investigated the effects of human menstrual blood stem cells (MenSCs)-derived exosomes in combination with hyperbaric oxygen therapy (HBOT) in the recovery of TSCI in rats.

Prevalence of Psychological Symptoms and Its Impact on the Quality of Life of Sickle Cell Disease Patients in Makkah, Saudi Arabia.

Background Patients with sickle cell disease (SCD), which is an inherited autosomal recessive disorder, experience a broad range of symptoms and complications such as acute chest syndrome, infections, strokes, seizures, etc. The main objective of this study was to assess the prevalence of depressive symptoms among SCD patients and determine the impact of sociodemographic factors and genotypes on depressive symptoms in Makkah City, Saudi Arabia. Methods A cross-sectional study was conducted among SCD patients aged 18 and above in the outpatient clinics in Makkah's four main hospitals (Al Noor Specialist Hospital, King Faisal Hospital, King Abdulaziz Hospital, and Hera General Hospital) from December 2021 to April 2022.

The Effect of Walnut Intake on Lipids: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Cardiovascular diseases (CVD) are the leading causes of death worldwide. Dyslipidemia is a cardiometabolic risk factor of CVD, yet it can be modifiable. Walnuts have been suggested as a dietary intervention to improve the lipid profile.

A Role for ER-Beta in the Effects of Low-Density Lipoprotein Cholesterol and 27-Hydroxycholesterol on Breast Cancer Progression: Involvement of the IGF Signalling Pathway?

Cholesterol-in particular, high levels of low-density lipoprotein (LDL) and its metabolite, 27-hydroxycholesterol (27-OHC)-is correlated with increases in the risks of breast cancer and obesity. Although the high expression of LDL/27-OHC has been reported in breast cancer, its effects and mechanism of action remain to be fully elucidated. In this study, we found that the effects of LDL on cell proliferation were mediated by the activation of the cytochrome P450 enzyme, sterol 27 hydroxylase, and cholesterol 27-hydroxylase (CYP27A1) in both ER-α-positive and ER-α-negative breast cancer cells.