Adenosine A Receptor Blockade Ameliorates Mania Like Symptoms in Rats: Signaling to PKC-α and Akt/GSK-3β/β-Catenin.

Adenosinergic system dysfunction is implicated in the pathophysiology of multiple neuropsychiatric disorders including mania and bipolar diseases. The established synergistic interaction between A and D receptors in the prefrontal cortex could highlight the idea of A receptor antagonism as a possible anti-manic strategy. Hence, the present study was performed to examine the effect of a selective adenosine A receptor blocker (SCH58261) on methylphenidate-induced mania-like behavior while investigating the underlying mechanisms.