The study focuses on diabetic nephropathy (DN) as a complication of diabetes mellitus (DM), investigating the role of oxidative stress and genetic variations in antioxidant enzymes like SOD2 and CAT among the Saudi population.
Involving 150 participants divided into three groups, the research used genetic testing to assess the association between specific single nucleotide polymorphisms (SNPs) and the risk of type 2 diabetes (T2D) and DN.
Results indicated that the SOD2 rs4880 SNP is linked to a significantly higher risk of DN in T2D patients, suggesting it may be a predictive marker for DN progression among these individuals.