Is radiation-induced ovarian ablation in breast cancer an obsolete procedure? Results of a meta-analysis.

Background: A meta-analysis was conducted to assess the impact of radiation-induced ovarian ablation (RT-OA) on amenorrhea cessation rates, progression-free survival, and overall survival in pre/perimenopausal women with breast cancer.

Materials And Methods: The Medline, CANCERLIT, and Cochrane Library databases and search engines were searched to identify randomized controlled studies comparing RT-OA with control for early or metastatic breast cancer. Further, radiotherapy doses, techniques, and associated side effects were evaluated.

Optic Nerve Metastasis from Squamous Cell Carcinoma of the Uterine Cervix.

Metastatic involvement of the optic nerve or its sheath is very rare (1.3 - 3%). The most common malignancies reported to metastasize to the optic nerve or its sheath are breast, lung, kidney, bladder, gastric and colorectal cancers.