Impact of Repetitive Transcranial Magnetic Stimulation on Cognitive and Psychiatric Dysfunction in Patients with Fibromyalgia: A Double-Blinded, Randomized Clinical Trial.

Few randomized controlled trials have reported that repetitive transcranial magnetic stimulation (rTMS) has controversial results for managing multiple domains of fibromyalgia-related symptoms. This work aimed to evaluate the effect of low-frequency rTMS over the right dorsolateral prefrontal area (DLPFC) on the Fibromyalgia Impact Questionnaire (FIQ) concerning psychiatric and cognitive disorders. Forty-two eligible patients with fibromyalgia (FM) were randomized to have 20 sessions of active or sham rTMS (1 Hz, 120% of resting motor threshold with a total of 1200 pules/session) over the right DLPFC.

Granzyme B Gene Polymorphisms Are Associated With Severe Non-segmental Vitiligo.

Background: Granzyme B (GZMB) gene is related to human immunity and is considered as one of the genes indulged in vitiligo.

Objective: To evaluate the association between GZMB (R55Q) and (P94Q) gene polymorphisms with vitiligo development in a sample of vitiligo Egyptian patients.

Methods: This study was a case-control study which included 100 non-segmental vitiligo patients as well as a control group consisted of 100 healthy, sex and age matched vitiligo free individuals.

Could α MSH-MIFT Axis and IDH2 be Considered Promising Predictors of Non-segmental Vitiligo Response to NB-UVB Phototherapy?

Background: The search for objective factors that help in predicting the response of vitiligo treatment is very important.

Objective: We sought to evaluate the effect of NB-UVB phototherapy on both the alpha melanocyte stimulating hormone-microphthalmia-associated transcription factor (α-MSH-MIFT) axis, and isocitrate dehydrogenase 2 (IDH2) in non-segmental vitiligo (NSV).

Methods: This prospective clinical trial included 50 NSV patients and 50 healthy control subjects.

Microbotox injection versus its topical application following microneedling in the treatment of wide facial pores: A split face comparative study.

Background: Enlarged facial pores and seborrhea are common cosmetic problems. Mesobotox has been proved to be effective safe therapeutic option.

Objective: To compare the efficacy and longevity of intradermal mesobotox injection versus its topical application with microneedling for treatment of wide facial pores and seborrhea.

Serum and salivary adipsin levels and its association with insulin resistance in acne vulgaris patients.

Background: There is scarcity in literature about the reliability of salivary markers in acne vulgaris.

Aims: The aims were to evaluate the insulin resistance (IR) and adipsin levels in serum and saliva in a sample of acne vulgaris patients; and to correlate IR and adipsin levels with the disease severity.

Methods: This prospective case-control study included 60 acne vulgaris patients (patients Group), in addition, 60 apparently healthy individuals (control group).

Methotrexate Mechanism of Action in Plaque Psoriasis: Something New in the Old View.

Background: Despite the era of biologic therapy in the management of psoriasis, methotrexate, the traditional backbone of psoriasis treatment, does not stop surprising us with what it can offer.

Objective: In this study, we aimed to evaluate the peripheral expression and the serum levels of TWEAK in patients with psoriasis vulgaris before and after receiving methotrexate treatment.

Methods: The study included 58 patients with moderate to severe psoriasis vulgaris, and 90 apparently healthy individuals as a control group.

Serum Neurotensin: An Objective Mirror to Acne-induced Quality of Life and Psychological Impairment.

Background: Acne is a multifactorial disorder, and stress potentially plays a role in its pathogenesis.

Objectives: We aimed to assess the serum levels of neurotensin in patients with acne vulgaris (AV) and investigate the relationship of these levels to quality of life (QoL), depression, anxiety, and stress.

Methods: The study included 60 patients with AV classified into mild (n=20), moderate (n=20), and severe (n=20) groups and 20 healthy, age-matched, sex-matched, and body mass index (BMI)-matched individuals in a control group.

Proteasome Subunit Beta Type-8 (PSMB8) Gene Polymorphisms in Vitiligo: A Possible Predictor of Auditory Involvement.

Introduction: Proteasome subunit beta type-8 (PSMB8) is a protein that contributes to the complete assembly of 20S proteasome complexes, which play a role in the pathogenesis of vitiligo.

Objective: The study aimed to evaluate the association between PSMB8 gene polymorphisms with vitiligo to assess its clinical significance among a sample of Egyptian patients with vitiligo.

Methods: Genomic DNA was isolated from blood samples of 100 patients with vitiligo and 100 control subjects, and detection of PSMB8 polymorphisms was done by real-time PCR.

Q-Switched 1064-nm Nd: YAG laser versus fractional carbon dioxide laser for post acne scarring: A split-face comparative study.

Objectives: Many treatment modalities are available for post acne scarring. However, the response to the treatment is extremely variable among patients.

Aim: The aim of this study was to compare the efficacy and safety of Q-switched Nd: YAG (1064 nm) and fractional CO (10,600 nm) lasers in the treatment of atrophic post acne scars.

Nuclear Factor Erythroid-2-related Factor 2 Gene Polymorphisms in Vitiligo.

Background: Oxidative stress is now one of the accepted theories of vitiligo development. Nuclear factor erythroid-2-related factor 2 (Nrf2) regulates the expression of antioxidant proteins.

Objective: This work aimed to evaluate the association of Nrf2 gene polymorphisms with the susceptibility to vitiligo among a sample of Egyptian patients with vitiligo.

Fluctuation in amino acids content in L. cultivars as an indicator on the impact of post-emergence herbicides in controlling weeds.

This study was carried out in a demonstrated field in El-Sharkia Governorate, Egypt, during the winter of season 2020 to evaluate the leverage of four post-emergence herbicides i.e., tribenuron-methyl, clodinafop- propargyl, pyroxsulam and pinoxaden compared to control on total protein and amino acid contents in three wheat cultivars (Shandwel 1, Giza 171, and Sakha 95).

MMP-1 (519 A/G) and TIMP-1 (372 T/C) genes polymorphism in an Egyptian sample of Acne vulgaris patients.

Background: Different Matrix metalloproteinases (MMPs) family members may be implicated in acne vulgaris development. However, there are no published data about the role of MMP-1 and TIMP-1 gene polymorphisms in acne vulgaris development.

Aims: To evaluate the association between MMP-1 (519 A/G) and TIMP-1 (372 T/C) gene polymorphisms and the risk of developing acne vulgaris among a sample of Egyptian acne patients.

Treatment of atrophic acne scars: Topical or intralesional plasma gel?

Background: Atrophic post-acne scarring is considered to be a therapeutic challenge.

Objectives: The aim was to compare the safety and efficacy of (A) FCL combined with intradermal injection of plasma gel, (B) FCL combined with topical application of plasma gel, and (C) FCL monotherapy in the treatment of atrophic post-acne scars.

Methods: Thirty patients with facial atrophic post-acne scars were enrolled in this study and randomly assigned into one of three groups.

HMGB1-RAGE-moesin axis may be indicted for acne vulgaris.

Background: High-mobility group box 1 (HMGB1)-receptor for advanced glycation end (RAGE)-moesin axis could be implicated in induction of inflammation. However, there is a scarcity in literature discussing the role of this axis in inflammatory skin disorders.

Aims: The aim of the present study was to evaluate the serum levels of HMGB1 and moesin in patients with inflammatory acne vulgaris.

Inflammatory markers in acne vulgaris: Saliva as a novel diagnostic fluid.

Background: Despite the wide use of saliva-based measurements in inflammatory, autoimmune and neoplastic conditions, its use in dermatology is still limited.

Aims: The aims of this study were to assess the serum and salivary levels of interleukin-1 beta (IL-1β) and C-reactive protein (CRP) in patients with acne vulgaris.

Patients/methods: The study included 84 moderate-to-severe acne vulgaris patients, in addition to 105 healthy control subjects.

Do the herbicides pinoxaden, tribenuron-methyl, and pyroxsulam influence wheat (Triticum aestivum L.) physiological parameters?

Herbicides reduce the unsafe effects of weeds, but they are likely to have negative impact on essential and secondary metabolism in crops. However, the combined effect of different herbicides on chemical constituents of different varieties of wheat is still not fully obvious. The current investigation was carried out to determine the effects of three post-emergence herbicides (pinoxaden, tribenuron-methyl, and pyroxsulam) on total protein, lipid, and carbohydrate concentrations of three bread wheat cultivars (Misr 1, Giza 171, and Gemmiza 11).

DEFB1 gene polymorphisms modify vitiligo extent and response to NB-UVB phototherapy.

Human beta defensin-1(hBD-1); an antimicrobial peptide, has immune regulatory effects which may be involved in autoimmunity. The aims were to evaluate the association between defensin beta 1 (DEFB1) (-44 C/G) and (-20 G/A) gene polymorphisms with the risk of vitiligo development, the extent of the disease and the response to NB-UVB treatment in a sample of Egyptian population. 178 active nonsegmental vitiligo patients and 182 control subjects were included in this prospective case control study.

Electrophoretic banding patterns of protein induced by pinoxaden, tribenuron-methyl, and pyroxsulam herbicides in wheat leaves (Triticum aestivum L.).

Herbicides are the most effective tool against weed flora in cereal crops that help to maintain and increase crop yields. This investigation was conducted in the winter season of 2018 to study the stress effect of three post-emergence herbicides including pinoxaden, tribenuron-methyl, and pyroxsulam on the biochemical changes at the molecular cell level of wheat. These herbicides were applied either lonely with a rate of 0.

Serum Zinc and Inflammatory Cytokines in Vitiligo.

The relation between zinc and the cytokines involved in vitiligo pathogenesis has not been studied well. We aimed to investigate the serum levels of zinc in patients with vitiligo and to assess their relation to serum interleukins (IL)-4, IL-6, and IL-17. The study included 50 patients with active vitiligo and 100 age-, sex-, and BMI-matched healthy volunteers as a control group.

Topical β-blockers for pyogenic granulomas: A promising option for younger patients.

Background: Topical β-blockers, propranolol, and timolol were used for pyogenic granuloma (PG) treatment; however, their efficacies and safety profiles were not compared.

Aims: The aim was to evaluate the safety and efficacy of propranolol 1% and timolol 0.5% creams in the treatment of pyogenic granulomas.

Factors affecting vitiligo response to treatment: do MiRNA 196a2C/T gene polymorphism and serum tyrosinase levels have any role?

Background: Factors contributing to the pathogenesis of vitiligo and factors affecting its response to treatment are still a major area of debate.

Aim Of The Work: The study aimed to assess the serum levels of tyrosinase and Micro-RNAs (miRNAs) gene polymorphism in a sample of Egyptian vitiligo patients, and to determine factors affecting the response of vitiligo to treatment.

Subjects And Methods: This prospective case-control interventional study included 212 non-segmental vitiligo patients and 96 control subjects.

Serum TWEAK: A cutoff between segmental and nonsegmental vitiligo.

Background: TWEAK/Fn14 is expressed in many tissues including the skin, playing an important role in many inflammatory, autoimmune, and neoplastic cutaneous disorders.

Aims: To assess the serum levels of tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in vitiligo patients.

Methods: This case-control study included 100 subjects (50 vitiligo patients and 50 control subjects) recruited from Dermatology Outpatient Clinic, Benha University.

Intra-articular injection of etanercept versus glucocorticoids in rheumatoid arthritis patients.

Objectives: This study was conducted to assess the safety and efficacy of intra-articular injection of etanercept and compare it with corticosteroid injection in rheumatoid arthritis (RA) patients.

Methods: Fifty patients with RA who suffered from activity in one joint were randomized into two groups, received an intra-articular injection of either etanercept or corticosteroid guided by musculoskeletal ultrasound. All patients were assessed for disease activity by disease activity score (DAS28), functional assessment using the Modified Health Assessment Questionnaire (MHAQ), and laboratory investigations (erythrocyte sedimentation rate and C-reactive protein).

High-resolution ultrasound for keloids and hypertrophic scar assessment.

Most of the widely used scales to evaluate scars are subjective relying on clinical observations. There is a growing need to find out a noninvasive objective tool for this purpose. The study is aimed at evaluating the value of the high-resolution ultrasound in the assessment of the scars when compared with a clinical evaluation scoring system, the Vancouver Scar Scale (VSS).