Female obesity is a worldwide health issue linked to chronic metabolic low-grade inflammation (metaflammation) causing multiple obesity-related co-morbid conditions. We aimed to assess the serum levels of wingless integration site family member 5 A (Wnt5a), leptin, and tumor necrosis factor-alpha (TNF-α) as markers of obesity-associated metaflammation and investigate the association with toll-like receptors2 (TLR2) gene (Arg753Gln) single nucleotide polymorphism (SNP) among Egyptian females. The study included 60 females with obesity and 30 matched controls.
View Article and Find Full Text PDFMultidrug-resistant (MDR) remains a significant global health threat. This study aimed to explore the potential of essential oil components as novel inhibitors of the MDR efflux pumps AcrAB and AcrD. isolates were characterized for serotype, antibiotic resistance, and efflux pump activity.
View Article and Find Full Text PDFIntroduction: Fanconi anemia (FA) is a genetic disorder characterized by bone marrow failure typically developing in the first decade of life, congenital abnormalities, and an increased predisposition to malignancy. However, patients with FA can remain undiagnosed until adulthood and present with solid organ malignancies. Due to impaired DNA repair mechanisms, patients with FA are highly susceptible to severe bone marrow toxicity when treated with cisplatin.
View Article and Find Full Text PDFThe recent advances in artificial intelligence modern approaches can play vital roles in the Internet of Medical Things (IoMT). Automatic diagnosis is one of the most important topics in the IoMT, including cancer diagnosis. Breast cancer is one of the top causes of death among women.
View Article and Find Full Text PDFQuantitative Structure Activity Relation (QSAR) models are mathematical techniques used to link structural characteristics with biological activities, thus considered a useful tool in drug discovery, hazard evaluation, and identifying potentially lethal molecules. The QSAR regulations are determined by the Organization for Economic Cooperation and Development (OECD). QSAR models are helpful in discovering new drugs and chemicals to treat severe diseases.
View Article and Find Full Text PDFBackground: Xanthenes and benzoxanthenesare are highly valuable compounds in organic chemistry and medicinal chemistry. Xanthene derivatives were found to have many applications in medicinal chemistry.
Objective: This work aims to explore the synthesis of xanthene derivatives with various substituents and find the possibility of their uses as anticancer agents.
Recently, pre-trained deep learning (DL) models have been employed to tackle and enhance the performance on many tasks such as skin cancer detection instead of training models from scratch. However, the existing systems are unable to attain substantial levels of accuracy. Therefore, we propose, in this paper, a robust skin cancer detection framework for to improve the accuracy by extracting and learning relevant image representations using a MobileNetV3 architecture.
View Article and Find Full Text PDFThe genus is widely distributed in aquatic environments and is recognized as a potential human pathogen. Some species are able to cause a wide spectrum of diseases, mainly gastroenteritis, skin and soft-tissue infections, bacteremia, and sepsis. The aim of the current study was to determine the prevalence of spp.
View Article and Find Full Text PDFDiagnostics (Basel)
February 2023
As day-to-day-generated data become massive in the 6G-enabled Internet of medical things (IoMT), the process of medical diagnosis becomes critical in the healthcare system. This paper presents a framework incorporated into the 6G-enabled IoMT to improve prediction accuracy and provide a real-time medical diagnosis. The proposed framework integrates deep learning and optimization techniques to render accurate and precise results.
View Article and Find Full Text PDFKidney Dis (Basel)
November 2022
Objective: The aim of this study was to reach a consensus on an updated version of the recommendations for the diagnosis and Treat-to-Target management of osteoporosis that is effective and safe for individuals with chronic kidney disease (CKD) G4-G5D/kidney transplant.
Methods: Delphi process was implemented (3 rounds) to establish a consensus on 10 clinical domains: (1) study targets, (2) risk factors, (3) diagnosis, (4) case stratification, (5) treatment targets, (6) investigations, (7) medical management, (8) monitoring, (9) management of special groups, (10) fracture liaison service. After each round, statements were retired, modified, or added in view of the experts' suggestions, and the percent agreement was calculated.
Curr Rheumatol Rev
October 2022
Background: Gout is one of the most common inflammatory arthritis, where identification of MSU crystals in synovial fluid is a widely used diagnostic measure. Ultrasonography has a great sensitivity in detecting signs of MSU deposits, such as tophi and double contour (DC), as mentioned in the latest gout criteria, allowing early clinical diagnosis and therapy.
Objective: The objective of this study was to evaluate the changes in ultrasound of gout patients' knee and 1st metatarsophalangeal joint (MTP1) after initiation of urate-lowering therapy (ULT) drugs in the six-month period.
Vitamin D plays a vital role in synthesizing calcium-carrying proteins in the small intestine and helps the absorption of calcium in the body, thus reducing the risk of rickets in children and osteoporosis in adults, especially in women. So, the objective of this study was to evaluate the nutritional value and quality characteristics of some food products such as waffles, breadsticks and salad cream fortified with dried mushroom powder (DMP) after exposure to sunlight for 60 min as a source of vitamin D. The exposure of mushroom to sunlight for 60 min before drying increased its content of vitamin D by 158% more than fresh mushroom (not exposed to sunlight).
View Article and Find Full Text PDFClin Med Insights Arthritis Musculoskelet Disord
April 2022
Background: In clinical practice, distinguishing disease activity in patients with rheumatological illnesses is challenging.
Objectives: We aimed to investigate clinical associations of hemogram-derived indices, namely: red cell distribution width (RDW), mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and systemic immune-inflammation index (SII) with disease activity in patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and ankylosing spondylitis (AS).
Methods: In 250 patients with rheumatological disease and 100 healthy age-matched controls, we investigated disease activity scores and indicators and evaluated their association with hemogram-derived indices values.
This study investigated the effect of supplementation with cantaloupe peel (CP) and seeds (CS) (3, 6, 9, and 12%) powder on the quality and antioxidant activity of raw and cooked chicken patties during storage (-20°C/3 months). The addition of CP and CS powder increased protein, fat, ash, and fiber values of chicken patties compared with control, while carbohydrate, pH, and TBA were decreased at zero time and after 3 months of storage. The WHC, cooking yield, fat retention, and moisture retention were increased by increasing CP and CS powder addition ratios, while cooking loss and shrinkage were decreased.
View Article and Find Full Text PDFCyclohexan-1,3-dione (1) reacted with either 2-aminoprop-1-ene-1,1,3-tricarbonitrile (2a) or diethyl 3-amino-2-cyanopent-2-enedioate (2b) to give the 5,6,7,8-tetrahydronaphthalene derivatives 3a and 3b, respectively. The latter compounds underwent further heterocyclization reactions to give the thieno[2',3':5,6]benzo[1,2-e][1,3]oxazine derivatives. On the other hand, the reaction of compound 1 with trichloroacetonitrile afforded the (2,2,2-trichloroethylidene)cyclohexane derivative 14.
View Article and Find Full Text PDFBackground: Various musculoskeletal and autoimmune manifestations have been described in patients with coronavirus disease 2019 (COVID-19). Objectives: This study aims to investigate the prevalence and etiology of arthritis in post-COVID Egyptian patients. Methods: We included 100 post-COVID Egyptian patients who recovered 6 months ago and assessed several inflammatory and autoimmune markers.
View Article and Find Full Text PDFThe development of pulmonary fibrosis is a rare complication of the novel coronavirus disease 2019 (COVID-19). Limited information is available in the literature about that, and the present study aimed to address this gap.This case-control study included 64 patients with post-COVID-19 pulmonary fibrosis who were hospitalized for COVID-19.
View Article and Find Full Text PDFInstead of the cloud, the Internet of things (IoT) activities are offloaded into fog computing to boost the quality of services (QoSs) needed by many applications. However, the availability of continuous computing resources on fog computing servers is one of the restrictions for IoT applications since transmitting the large amount of data generated using IoT devices would create network traffic and cause an increase in computational overhead. Therefore, task scheduling is the main problem that needs to be solved efficiently.
View Article and Find Full Text PDFBackground: 1,3-Diones are versatile reagents used for many heterocyclic transformations. Among such groups of compounds, cyclohexane-1,3-dione is widely used in organic synthesis to produce biologically active compounds.
Objective: In this work, target molecules were synthesized from tetrahydrobenzo[b]thiophen-3- carboxamide derivative with different substituents, and their structure-activity relationships were discussed in detail.
With the widespread use of intelligent information systems, a massive amount of data with lots of irrelevant, noisy, and redundant features are collected; moreover, many features should be handled. Therefore, introducing an efficient feature selection (FS) approach becomes a challenging aim. In the recent decade, various artificial methods and swarm models inspired by biological and social systems have been proposed to solve different problems, including FS.
View Article and Find Full Text PDFKombucha is a traditional beverage of sweetened black tea fermented with a symbiotic association of acetic acid bacteria and yeasts. In this study, kombucha fermented beverage (KFB) appeared to include nine chemical groups (alcohols, acids, lactones, condensed heterocyclic compounds, antibiotics, esters, aldehydes, fatty acids, and alkaloids) of many bioactive metabolites, as elucidated by gas chromatography-mass spectrometry (GC-MS) and IR spectra. The fermented metabolic components of KFB seem collectively to act in a synergistic action giving rise to the antimicrobial activity.
View Article and Find Full Text PDFIn this work the multi-component reactions of either of the arylhydrazocyclohexan-1,3-dione derivatives 3a-c with either of benzaldehyde (4a), 4-chlorobenzaldehyde (4b) or 4-methoxybenzaldehyde (4c) and either malononitrile (5a) or ethyl cyanoacetate (5b) giving the 5,6,7,8-tetrahydro-4H-chromene derivatives 6a-r, respectively, are presented. The reaction of two equivalents of cyclohexan-1,3-dione with benzaldehyde gave the hexahydro-1H-xanthene-1,8(2H)-dione derivative 7. On the other hand, the multi-component reactions of compound 1 with dimedone and benzaldehyde gave 13.
View Article and Find Full Text PDFKefir beverage (KB) is a fermented milk initiated by kefir grains rich with starter probiotics. The KB produced in this study seemed to contain many chemical compounds elucidated by gas chromatography-mass spectrometry (GC-MS) and IR spectra. These compounds could be classified into different chemical groups such as alcohols, phenols, esters, fatty esters, unsaturated fatty esters, steroids, polyalkenes, heterocyclic compounds and aromatic aldehydes.
View Article and Find Full Text PDFCOVID-19 is a new member of the Coronaviridae family that has serious effects on respiratory, gastrointestinal, and neurological systems. COVID-19 spreads quickly worldwide and affects more than 41.5 million persons (till 23 October 2020).
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