Publications by authors named "Regitze Videbaek"
Article Synopsis
- The Danish Study (DANISH) aimed to evaluate the impact of implantable cardioverter-defibrillators (ICD) on health-related quality of life (HRQoL) in patients with non-ischaemic systolic heart failure, despite finding no overall effect on mortality.
- In the study, 1116 patients were randomly assigned to receive either ICD implantation or standard care, with HRQoL assessed using the Minnesota Living with Heart Failure Questionnaire (MLHFQ) over 8 months.
- Results indicated that there were no significant differences in HRQoL improvements between the ICD group and the control group, suggesting that ICD implantation did not enhance quality of life for these patients.
Background: The DANISH study (Danish Study to Assess the Efficacy of ICDs [Implantable Cardioverter Defibrillators] in Patients With Non-Ischemic Systolic Heart Failure on Mortality) did not demonstrate an overall effect on all-cause mortality with ICD implantation. However, the prespecified subgroup analysis suggested a possible age-dependent association between ICD implantation and mortality with survival benefit seen only in the youngest patients. The nature of this relationship between age and outcome of a primary prevention ICD in patients with nonischemic systolic heart failure warrants further investigation.
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- The study investigated the impact of implantable cardioverter-defibrillators (ICDs) on patients with symptomatic systolic heart failure not caused by coronary artery disease, comparing ICD treatment with usual clinical care.
- A total of 1,116 patients were enrolled, and after 67.6 months, it was found that ICDs did not significantly lower overall mortality rates compared to the control group, although they did reduce instances of sudden cardiac death.
- The findings suggest that while ICDs may have benefits for sudden cardiac death prevention, they do not significantly improve long-term survival rates in this specific patient population.
Study Design and Cohort Description of DEFIB-WOMEN: A National Danish Study in Patients with an ICD.
Pacing Clin Electrophysiol
November 2016
Background: Little systematic evidence is available on potential gender differences in patients with an implantable cardioverter defibrillator (ICD) from a real-world cohort. We designed the DEFIB-WOMEN (The Utilization of Implantable Cardioverter DEFIBrillator Therapy in the Treatment of Heart Disease: Clinical and Psychological outcomes in WOMEN) study to examine gender differences on (1) patient-reported outcomes (PROs), (2) procedure- and device-related complications, and (3) ventricular tachyarrhythmia and mortality. This presents the study design and baseline characteristics of the cohort.
View Article and Find Full Text PDFObjective: Cardiovascular implantable electronic device (CIED) infections are increasing in numbers. The objective was to review the clinical presentation and outcome in patients affected with CIED infections with either local pocket or systemic presentation.
Design: All device removals due to CIED infection during the period from 2005 to 2012 were retrospectively reviewed.
Background: The natural history of insulation defects with inside-out conductor externalization in recalled St Jude Medical Riata defibrillator leads is not well understood.
Objectives: To determine the prevalence of externalization in a nationwide screening. Secondary aims were to examine time dependence and location of externalization, association with electrical failure, and fluoroscopic diagnostic performance.
Aims: To evaluate the incidences of and risk factors predisposing to appropriate and inappropriate shocks and mortality in a 'real-world' population of patients with ischaemic heart disease (IHD) and implantable cardioverter defibrillators (ICD) for primary prevention of sudden cardiac death (SCD).
Methods And Results: In this nationwide cohort, we prospectively followed 1609 patients with IHD and left ventricular dysfunction from the Danish ICD Register who received an ICD for primary prevention of SCD (1 January 2007 to 30 November 2011). Primary study outcomes were appropriate shocks, inappropriate shocks, and all-cause mortality.
Background: The prevalence, prognostic importance, and factors that predict the presence and degree of pulmonary hypertension (PH) diagnosed with right heart catheterization (RHC) in patients with end-stage chronic obstructive pulmonary disease (COPD) remain unclear.
Methods: This retrospective study included 409 patients (61% women) with COPD/emphysema or α-1-antitrypsin deficiency who underwent lung transplant evaluation during 1991 to 2010. We analyzed the occurrence and degree of PH and compared demographics, oxygenation, lung function, hemodynamics, functional capacity, and survival in patients with and without PH.
Aims: The aim of this study was to examine health-care professionals attitudes towards implantable cardioverter-defibrillator (ICD) therapy and issues discussed with patients.
Methods And Results: Survey of 209 health-care professionals providing specialized treatment and care of ICD patients at the five implanting centres in Denmark. Questions pertained to gender, age, years of experience within the field, knowledge of the ongoing critical debate on ICD therapy, and personal experience with ICD treatment, and/or sudden cardiac arrest within family and/or friends.
Article Synopsis
- The study explores the safety of conducting MRI scans in patients with cardiac implants like pacemakers and ICDs, which are typically seen as contraindications for such procedures.
- Over nine years, 65 patients underwent 73 MRI exams, with precautions taken like reprogramming devices to prevent issues during scans.
- Results showed that while most MRIs were safe, there were rare instances of device inhibition and induction of complications, especially in ICD patients, indicating that MRI remains experimental for them.
Background: Severe pulmonary sarcoidosis is often complicated by pulmonary hypertension (PH) caused by different pathophysiological mechanisms.
Objectives: To assess the acute vasoresponsiveness in patients with sarcoidosis and PH and the relation to the therapeutic effect of sildenafil.
Methods: A retrospective chart review of 25 patients with recalcitrant pulmonary sarcoidosis being evaluated for lung transplantation at our centre.
Article Synopsis
- * Results showed that 52% of patients experienced sustained VT/VF, mostly within the first four weeks after receiving the LVAD.
- * Eight patients needed defibrillation treatments due to VT/VF, and the authors suggest implementing preventive measures, like implantable cardioverter-defibrillators (ICDs), for patients on continuous-flow LVAD support, despite not finding clear risk predictors.
Background: The objectives of this study were to assess the frequency and severity of pulmonary hypertension (PH) and the effect of sildenafil treatment in patients with recalcitrant pulmonary sarcoidosis.
Methods: This investigation was a single-center, retrospective study of all patients (n = 25) with end-stage pulmonary sarcoidosis referred for lung transplantation. Hemodynamic measurements were evaluated by right-side cardiac catheterization in 24 of 25 patients.
Objectives: Dyspnea is a major symptom of both parenchymal lung disease and chronic heart failure. Underlying cardiac dysfunction can be assessed by measurement of cardiac-derived B-type natriuretic peptide or its precursor in plasma. However, no specific endocrine marker of the lung parenchyma has so far been identified.
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- Plasma concentrations of BNP-32 and proBNP are elevated in chronic heart failure and are being used as clinical markers to assess heart failure severity.
- A study found that patients with severe heart dysfunction had significantly higher levels of both BNP-32 and proBNP in their blood compared to normal subjects, with strong correlations between these levels in different regions of the heart.
- The results indicate that while peripheral levels of both markers are similar, BNP-32 is more concentrated than proBNP in the coronary sinus, suggesting coordinated secretion patterns in heart failure.
Background: Increased plasma concentrations of pro-atrial natriuretic peptide (proANP) and pro-brain natriuretic peptide (proBNP) are features of left ventricular impairment. However, concentrations of proANP and proBNP in patients with isolated terminal parenchymal lung disease are not known. Therefore, we measured the plasma concentrations of natriuretic precursor peptides in patients with terminal parenchymal lung disease who had normal left ventricular function and who were referred for evaluation for lung transplantation.
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- CAG is a costly but informative procedure that poses risks, prompting an analysis of its existing database from Rigshospitalet between 1999 and 2000.* -
- Out of 5,536 CAGs recorded, 52% were for stable coronary artery disease, and the database revealed essential insights, such as significant left main coronary stenosis found in 42.4% of CCS class 4 patients.* -
- The clinical database aids in effective information storage, emphasizing that angina severity alone doesn't predict which patients would benefit most from surgery, and supports various aspects of medical training and administrative planning.*
Article Synopsis
- A study evaluated a new infrared photoacoustic gas analyzer for measuring cardiac output and pulmonary blood flow in patients with heart failure or pulmonary hypertension.
- Results showed that the gas rebreathing method provided measurements comparable to traditional methods (direct Fick and thermodilution) with minimal bias, especially after correcting for shunt flow.
- The findings suggest that this new method can reliably estimate cardiac output, offering a convenient option for clinicians treating cardiovascular disease patients.