Publications by authors named "Regina Weil"
Three haplotypes associated with CYP2A6 phenotypes in Caucasians.
Pharmacogenet Genomics
September 2005
The human cytochrome P450 2A6 (CYP2A6) enzyme metabolizes several xenobiotic compounds of clinical or toxicological importance. We aimed to identify genetic variants and major CYP2A6 haplotypes associated with CYP2A6 phenotypic variation. CYP2A6 mRNA level, protein level, activity and haplotypes were determined in Caucasian liver samples via real-time polymerase chain reaction, Western blot, coumarin 7-hydroxylation, DNA sequencing and genotyping, respectively.
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- The study analyzed the expression levels of four CYP3A genes (CYP3A4, CYP3A5, CYP3A7, and CYP3A43) across various tissues, revealing that CYP3A4 is significantly more prevalent in the liver compared to the others.
- CYP3A5 and CYP3A7 showed some variability in expression, particularly in certain livers that carried specific genetic markers, while CYP3A43 had minimal presence.
- The findings highlight the complexity of CYP3A gene regulation and its potential implications for drug metabolism and individual responses to medications.