Publications by authors named "Regina Stasser de Gonzalez"
ACS Chem Biol
August 2024
Article Synopsis
- Rhomboid proteases, including human RHBDL4, are important due to their roles in protein degradation and disease, particularly cancer, but effective chemical tools to study them have been lacking.
- An activity-based protein profiling (ABPP) assay was developed specifically for RHBDL4, revealing that it undergoes processing to form active proteoforms with shorter C-termini in cells.
- The study also identified specific chemical compounds that can inhibit RHBDL4 and showed that there are differences in inhibitor preferences between RHBDL4 and another rhomboid protease called PARL, highlighting the utility of ABPP for enzyme characterization and selective targeting.
