In Situ Dual Cross-Linking of Neat Biogel with Controlled Mechanical and Delivery Properties.

Injectable biomaterials play a critical role in many biomedical applications. These materials, however, often have limitations in mechanical and drug-eluting properties attributed to their high water content and the weak secondary forces holding them together. Here we describe a new injectable material based on two complementary water-free, prepolymers modified with succinimidyl carbonate (SC) or with NH end groups that form a stiff matrix upon mixing.

Strong tissue glue with tunable elasticity.

Unlabelled: Many bio-adhesive materials adhere weakly to tissue due to their high water content and weak structural integrity. Others provide desirable adhesive strength but suffer from rigid structure and lack of elasticity after administration. We have developed two water-free, liquid four-armed PEG pre-polymers modified with NHS or with NH end groups which upon mixing changed from liquids to an elastic solid.