Publications by authors named "Regina Kahleova"
Article Synopsis
- Elevated homocysteine levels in coronary artery disease (CAD) are debated as either a cause or consequence, but genetic variants affecting homocysteine metabolism could imply a causal role.
- A study analyzed 11 genetic variants related to the methionine cycle in 591 control subjects and 278 CAD patients, finding that the c.844ins68 variant in the CBS gene significantly reduced CAD risk.
- Healthy individuals with the c.844ins68 variant had better metabolic ratios linked to improved methylation and homocysteine processing, suggesting that homocysteine metabolism may influence CAD development or progression.
Background: Although insulin resistance and elevated plasma homocysteine are associated with hypertension in adults, the role of these conditions in the initial phase of hypertension is largely unknown. We examined whether insulin resistance and disturbed homocysteine metabolism are present in young adults at the early stages of essential hypertension.
Methods: We measured physical characteristics, plasma levels of insulin, lipids, total homocysteine, and vitamins in 164 patients with essential juvenile hypertension (median age, 19 years; 92% males) and in 173 controls (median age, 18 years; 66% males).