Idarucizumab administration in emergency situations: the Munich Registry of Reversal of Pradaxa® in clinical routine (MR REPAIR).

Objectives: To evaluate daily life management and functional outcome of Idarucizumab administration in case of emergency situations in patients with Dabigatran treatment.

Design: Multicenter observational registry study.

Setting: All hospitals with full neurological departments (n = 6) in Munich, Germany INCLUDED PATIENTS: All patients treated with Idarucizumab from 01/2016 to 03/2019.

Cortical alterations in phobic postural vertigo - a multimodal imaging approach.

Objective: Functional dizziness syndromes are among the most common diagnoses made in patients with chronic dizziness, but their underlying neural characteristics are largely unknown. The aim of this neuroimaging study was to analyze the disease-specific brain changes in patients with phobic postural vertigo (PPV).

Methods: We measured brain morphology, task response, and functional connectivity in 44 patients with PPV and 44 healthy controls.

Predictive Capability of an iPad-Based Medical Device (mex) for the Diagnosis of Vertigo and Dizziness.

Background: Making the correct diagnosis of patients presenting with vertigo and dizziness in clinical practice is often challenging.

Objective: In this study we examined the performance of the iPad based program mex in the prediction of different clinical vertigo and dizziness diagnoses and as a diagnostic tool to distinguish between them.

Patients And Methods: The data collection was done in the outpatient clinic of the German Center of Vertigo and Balance Disorders.

Chronic subjective dizziness: Fewer symptoms in the early morning--a comparison with bilateral vestibulopathy and downbeat nystagmus syndrome.

Objective: Chronic subjective dizziness (CSD) is a form of chronic dizziness. Many patients report fewer symptoms when they get up with an aggravation over of the day. Therefore, the change in the severity of the symptoms during daytime was evaluated and compared with other chronic vestibular diseases: bilateral vestibulopathy (BVP) and downbeat nystagmus (DBN).

Assessment of cerebral dopamine D 2/3 formula-receptors in patients with bilateral vestibular failure.

Background: Absence of peripheral vestibular input in bilateral vestibular failure (BVF) has been suggested to induce plastic reorganization in various brain regions. Among several neurotransmitters, dopamine is known to play a key role in cortico-striatal-sensorimotor processing. However, the role of dopamine in vestibular plasticity is scantly documented.

Psychiatric comorbidity and psychosocial impairment among patients with vertigo and dizziness.

Background: Vertigo and dizziness are often not fully explained by an organic illness, but instead are related to psychiatric disorders. This study aimed to evaluate psychiatric comorbidity and assess psychosocial impairment in a large sample of patients with a wide range of unselected organic and non-organic (ie, medically unexplained) vertigo/dizziness syndromes.

Methods: This cross-sectional study involved a sample of 547 patients recruited from a specialised interdisciplinary treatment centre for vertigo/dizziness.

Effects of acetyl-DL-leucine in patients with cerebellar ataxia: a case series.

No existing medication has yet been shown to convincingly improve cerebellar ataxia. Therefore, the identification of new drugs for its symptomatic treatment is desirable. The objective of this case series was to evaluate the efficacy of treatment of cerebellar ataxia with the amino acid acetyl-DL-leucine (Tanganil).

Separating distinct aspects of the voluntary selection between response alternatives: N2- and P3-related BOLD responses.

Voluntary selection between response alternatives belongs to cognitive abilities controlling and regulating goal-directed behaviour. Voluntary selection processes are associated with increased neural activity, especially in medial and lateral frontal brain regions as well as the inferior parietal gyrus. However, the precise function of each brain region as well as the spatiotemporal characteristic of the brain regions involved is not yet clear.