Publications by authors named "Regina Dagher"
Article Synopsis
- Standard testing for B-cell acute lymphoblastic leukemia (B-ALL) typically involves examining the bone marrow and cerebrospinal fluid, with imaging used in cases of suspected extramedullary disease, although not routinely for relapsed/refractory cases.
- This text discusses two patients with relapsed/refractory B-ALL who had previously received treatments and were assessed to only have minimal residual disease (MRD) before CAR-T cell therapy.
- Both patients underwent PET-MRI scans before treatment, which unexpectedly revealed significant extramedullary disease, necessitating adjustments in their clinical management and emphasizing the need for more thorough imaging studies in future B-ALL treatment protocols.
Centrosome amplification has long been recognized as a feature of human tumours; however, its role in tumorigenesis remains unclear. Centrosome amplification is poorly tolerated by non-transformed cells and, in the absence of selection, extra centrosomes are spontaneously lost. Thus, the high frequency of centrosome amplification, particularly in more aggressive tumours, raises the possibility that extra centrosomes could, in some contexts, confer advantageous characteristics that promote tumour progression.
View Article and Find Full Text PDFThe involvement of whole-chromosome aneuploidy in tumorigenesis is the subject of debate, in large part because of the lack of insight into underlying mechanisms. Here we identify a mechanism by which errors in mitotic chromosome segregation generate DNA breaks via the formation of structures called micronuclei. Whole-chromosome-containing micronuclei form when mitotic errors produce lagging chromosomes.
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