Publications by authors named "Regina C Ahmad"
Proc Natl Acad Sci U S A
August 2006
Article Synopsis
- Researchers have identified a specific T cell epitope of proinsulin (P-Ins)(73-90) that is significant for individuals with beta-islet cell autoimmunity and in certain mouse models.
- The study reveals that while human and mouse T cell clones recognize the same epitope, they differ significantly in their interactions with the peptide/HLA complex due to the immune context (autoantigen in humans vs. foreign antigen in mice).
- The findings suggest that modifications to the peptide can alter T cell responses, indicating the potential for targeting this P-Ins epitope for therapeutic interventions in people with type 1 diabetes.
