Publications by authors named "Regiane N Spalanzani"
Article Synopsis
- Invasive candidiasis (IC) caused by non-albicans Candida is on the rise globally, especially in pediatrics, but there is limited data on its characteristics and treatment responses in children.
- A study in a southern Brazilian children's hospital analyzed 123 non-duplicate Candida isolates from 2016 to 2021, finding a range of IC incidence between 0.88-1.55 cases per 1000 hospitalized patients and a mortality rate of 20.3%, with many cases occurring in patients under 13 months and linked to ICU admissions.
- The research noted that the predominant species were non-albicans Candida (70.8%), with most isolates producing biofilm, but there was no significant clonal
Carbapenem-resistant Klebsiella pneumoniae (CRKP) exhibit high mortality rates in pediatric patients and usually belong to international high-risk clones. This study aimed to investigate the molecular epidemiology and carbapenem resistance mechanisms of K. pneumoniae isolates recovered from pediatric patients, and correlate them with phenotypical data.
View Article and Find Full Text PDFInvasive candidiasis (IC) contributes to the morbidity and mortality of hospitalized patients and represents a significant burden to the healthcare system. Previous Brazilian studies have reported the presence of endemic sensu stricto genotypes causing candidemia and clonal transmission involving fluconazole-resistant isolates. We performed a 5-year retrospective analysis of IC cases in a Brazilian tertiary pediatric hospital and conducted a molecular investigation of sensu stricto.
View Article and Find Full Text PDFThe nasopharyngeal swab is a gold standard for detecting SARS-CoV-2. However, the inconvenience of this method compelled us to compare its efficiency with saliva and gargle samples, which we collected sequentially from 229 individuals. Saliva outperformed gargle samples, constituting a reliable RNA viral source with similar performance to nasopharyngeal samples.
View Article and Find Full Text PDFArticle Synopsis
- A study conducted in Curitiba, Brazil, aimed to analyze the characteristics of COVID-19 among healthcare workers (HCWs) by testing over 1,000 samples for the virus between June and December 2020.* -
- Results indicated that 32.7% of HCWs tested positive for SARS-CoV-2, with higher infection rates found among symptomatic (39.2%) compared to asymptomatic (15.9%) workers; high-risk hospital departments had the most cases.* -
- The study highlights the importance of early diagnosis and isolation of infected HCWs to help control the spread of the virus, especially since those in direct contact with COVID-19 patients have a higher risk of infection.*
Objective: To assess the diagnostic performance of lateral flow immunochromatographic assays (LFAs) of 4 different manufacturers to identify SARS-CoV-2 antibodies (IgM, IgG, or total), comparing them with the nucleic acid amplification test (NAAT) or the clinical defined test (definite or probable SARS-CoV-2 infection, respectively).
Methods: One hundred nineteen serum samples were randomly selected by convenience and distributed in the following groups: (1) group with SARS-CoV-2 infection (n = 82; RT-qPCR positive [definite, n = 70] and probable [n = 12]); (2) other diseases (n = 27; other viruses identified [n = 8] and SARS of other etiologies [n = 19]); and (3) healthy control group (n = 10). LFAs of 4 manufacturers were compared: MedTest Coronavirus (COVID-19) IgG/IgM (MedLevensohn, Brazil); COVID-19 IgG/IgM ECO Test (Ecodiagnóstica, Brazil); Camtech COVID-19 IgM/IgG Rapid Test Kit (Camtech Diagnostics Pte Ltd, Singapore); and 1-Step COVID-19 Test for total antibodies (Guangzhou Wondfo Biotech Co.
Introduction: We describe the clinical and laboratorial features of oral candidiasis in 66 HIV-positive patients.
Methods: Polymerase chain reaction-based techniques were performed for differentiation of Candida spp. isolated from patients at a public teaching hospital in Midwest Brazil.