Publications by authors named "Regan Mah"
Article Synopsis
- Clostridioides difficile is a concerning bacteria linked to severe recurrent infections, especially in patients with inflammatory bowel disease (IBD), where about 25% experience repeat infections.
- The study collected blood and stool samples from IBD patients and healthy controls to assess the immune response to C. difficile and analyze the gut microbiome through advanced techniques.
- Findings revealed that IBD patients have higher levels of specific immune cells linked to C. difficile infection, but reduced T helper cells, suggesting possible undiagnosed infections and a relationship between C. difficile and inflammation in IBD, highlighting the need for testing in these patients.
Background: Diagnosis of Clostridioides difficile Infection (CDI) entails compatible clinical presentation and laboratory findings. We evaluated real-time polymerase chain reaction (qPCR) cycle threshold (C) as a predictor for disease severity and TcdB enzyme immunoassay (EIA) results.
Methods: Inpatients or emergency department patients who tested positive for tcdB gene by PCR were evaluated.