Publications by Regan B Kirkpatrick

Publications by authors named "Regan B Kirkpatrick"

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Homeostatic coordination of cellular phosphate uptake and efflux requires an organelle-based receptor for the inositol pyrophosphate IP8.

Xingyao Li Regan B Kirkpatrick Xiaodong Wang Charles J Tucker Anuj Shukla

Cell Rep

June 2024

Phosphate (Pi) serves countless metabolic pathways and is involved in macromolecule synthesis, energy storage, cellular signaling, and bone maintenance. Herein, we describe the coordination of Pi uptake and efflux pathways to maintain mammalian cell Pi homeostasis. We discover that XPR1, the presumed Pi efflux transporter, separately supervises rates of Pi uptake.

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- Regan B Kirkpatrick's recent research focuses on the role of inositol pyrophosphate IP8 in regulating phosphate (Pi) homeostasis in mammalian cells, highlighting its crucial metabolic functions.
- The study reveals that the transporter XPR1, traditionally seen as a Pi efflux transporter, also plays an active role in managing the rates of Pi uptake, indicating a more complex coordination of phosphate transport mechanisms than previously understood.
- The findings underline the importance of organelle-based receptors in maintaining cellular phosphate levels, which have significant implications for various physiological processes including energy storage and cellular signaling.

Publications by authors named "Regan B Kirkpatrick"

Homeostatic coordination of cellular phosphate uptake and efflux requires an organelle-based receptor for the inositol pyrophosphate IP8.

Synopsis of recent research by authors named "Regan B Kirkpatrick"