Publications by authors named "Refniwita Yasril"
Article Synopsis
- Lung cancer patients with EGFR gene mutations receive treatment using tyrosine kinase inhibitors (TKIs), and the study aimed to assess methods for detecting these mutations in cell-free DNA before and after treatment.
- Using various techniques (PCR-HRM, RFLP, and direct sequencing), researchers analyzed samples from 116 treatment-naïve patients and found that while 100% of cfDNA samples showed EGFR genotypes, the sensitivity of plasma testing for mutations was relatively low compared to cytological samples.
- After three months of TKI treatment, new resistance mutations were detected in some patients' plasma, suggesting that these tests can identify treatment resistance early on despite low sensitivity in detecting certain mutations.
Indonesia has the highest cigarette consumption in the world. We explored the clinical impact of smoking on the prevalence of and mutations and survival in this prospective study. 143 treatment naive lung cancer patients were recruited from Persahabatan Hospital, a national tertiary hospital.
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