Maternal alloxan exposure induces damage in rat offspring lumbar vertebrae and protective role of arachidonic acid.

Background: Vertebral abnormalities in offspring of diabetic mothers make major challenges worldwide and were not sufficiently studied before.

Aim: To investigate the effects of alloxan-induced diabetes on rats' lumbar vertebrae, and to assess the potential beneficial impact of arachidonic acid.

Materials And Methods: Pregnant rats were randomly equally divided into four groups: control, alloxan-induced diabetes received alloxan injection 150 mg∕kg, alloxan + arachidonic acid group received arachidonic acid 10 μg∕animal then given alloxan injection, and arachidonic acid group received it, until offspring age of three weeks.