Network-based approach highlighting interplay among anti-hypertensives: target coding-genes: diseases.

Elucidating the relation between the medicines: targets, targets: diseases and diseases: diseases are of fundamental significance as-is for societal benefit. Hypertension is one of the dangerous health conditions prevalent in society, is a risk factor for several other diseases if left untreated and anti-hypertensives (AHs) are the approved drugs to treat it. The goal of the study is to decipher the connection between hypertension with other health conditions, however, is challenging due to the large interactome.

An Exploration of Electrocatalytic Analysis and Antibacterial Efficacy of Electrically Conductive Poly (D-Glucosamine)/Graphene Oxide Bionanohybrid.

The diversification of environment congenial and conservative nanocomposites is prestigious because of increasing contamination in biota. Poly (D-glucosamine), a natural biopolymer is contemplated as a promising biodegradable polysaccharide for various applications mainly in food packaging, bone substitutes, and water filtration. The drawback of poly (D-glucosamine) is nadir mechanical strength and high hydrophilicity which could be amended by the introduction of graphene oxide (GO) nanoparticles (shows excellent load transfer).

Data science-driven analyses of drugs inducing hypertension as an adverse effect.

The utilization of approved medication is a requisite to combat certain diseases for health; however, the undesirable adverse effects (AEs) due to medication are generally unavoidable. Hypertension is one of such AEs resulting from approved medication in which blood pressure in the arteries gets elevated and is a risk factor for several diseases including heart and kidney failure. HTs are the approved drugs that can cause hypertension as an AE.

Ethylenediamine-assisted growth of multi-dimensional ZnS nanostructures and study of its charge transfer mechanism on supercapacitor electrode and photocatalytic performance.

In recent years, much interest has been raised by materials with multi-purpose characteristics as the performance of electrochemical energy devices such as supercapacitors and photocatalytic activities depend strongly on the properties of materials. This study delineates various parameters like morphology, energy band gap, charge transfer resistance, different defect states, diffusion coefficient and functional groups adsorbed on the surface of material to assess the performance of supercapacitor electrodes and photocatalytic degradation efficiency of synthesised multi-dimensional ZnS nanostructures. Ethylenediamine (EN)-mediated multi-dimensional ZnS nanostructures were grown by the solvothermal route.

Elucidating the preference of dimeric over monomeric form for thermal stability of Thermus thermophilus isopropylmalate dehydrogenase: A molecular dynamics perspective.

An oligomer usually refers to a macromolecular complex formed by non-covalent interactions of monomers. Several thermophilic proteins are oligomers. The significance of oligomerization of individual proteins for stability at higher temperature is of prime importance for understanding evolution and increasing industrial productivity.

Clinical evaluation of powder ( Linn.) and (paste of leaves of Linn.) in the management of (eczema).

Background: In , majority of skin diseases have been mentioned under the umbrella of and in other words, it can be listed as " dermatology." Among them, (eczema) included under , has been mentioned as curable disease, but due to relapsing nature of the disease and hazardous side effects of the modern drugs, it is difficult to manage. classics described a number of formulations to combat (skin diseases) which offers effective remedy for eczema.

Deciphering the Dynamics of Non-Covalent Interactions Affecting Thermal Stability of a Protein: Molecular Dynamics Study on Point Mutant of Thermus thermophilus Isopropylmalate Dehydrogenase.

Thermus thermophilius isopropylmalate dehydrogenase catalyzes oxidative decarboxylation and dehydrogenation of isopropylmalate. Substitution of leucine to alanine at position 172 enhances the thermal stability among the known point mutants. Exploring the dynamic properties of non-covalent interactions such as saltbridges, hydrogen bonds and hydrophobic interactions to explain thermal stability of a protein is interesting in its own right.

Community level workers: awareness generation for improving children's health.

Background: Routine immunisation and Vitamin A supplementation are two of many services offered by Government of India to reduce child mortality and morbidity. The three groups of community level workers (CLWs) i.e.

thrombolytic activity of ( Linn.), ( Decne.), and ( Thunb.).

Introduction: Thrombotic disorders are among the major fatal conditions affecting the society. Treatment modalities used for such disorders are either surgical interventions or use of drugs such as urokinase, streptokinase (SK), or tissue plasminogen activators to dissolve the blood clots. These modalities have their own limitations and side effects apart from being expensive.

Factors affecting the performance of community health workers in India: a multi-stakeholder perspective.

Background: Community health workers (CHWs) form a vital link between the community and the health department in several countries. In India, since 2005 this role is largely being played by Accredited Social Health Activists (ASHAs), who are village-level female workers. Though ASHAs primarily work for the health department, in a model being tested in Rajasthan they support two government departments.

A study on the method of Taila Bindu Pariksha (oil drop test).

Taila Bindu Pariksha, an ancient method of urine examination for ascertaining the prognosis of diseases, was very popular in the medieval period, the use of which became obsolete after 17(th) Century AD. Technique of this test is very crude and there are chances of variations in the observations. To revive this technique, it is necessary that the methodology of this test should be standardized so that the observations could be reproducible.

Validation of drug-like inhibitors against Mycobacterium tuberculosis L-aspartate α-decarboxylase using nuclear magnetic resonance (1H NMR).

The catalytic activity of L-aspartate α-decarboxylase (ADC) is essential for the growth of several micro-organisms, including Mycobacterium tuberculosis (Mtb), and has triggered efforts for the development of pharmaceutically active compounds against tuberculosis. The present study is a continuation of our recent chemoinformatics-based design approach for identifying potential drug-like inhibitors against MtbADC. We report an NMR-based protocol that allows label-free and direct monitoring of enzymatic conversion, which we have combined with a systematic testing of reported and newly identified potential inhibitors against MtbADC.

Chemoinformatic identification of novel inhibitors against Mycobacterium tuberculosis L-aspartate α-decarboxylase.

L-aspartate α-decarboxylase (ADC) belongs to a class of pyruvoyl dependent enzymes and catalyzes the conversion of aspartate to β-alanine in the pantothenate pathway, which is critical for the growth of several micro-organisms, including Mycobacterium tuberculosis (Mtb). Its presence only in micro-organisms, fungi and plants and its absence in animals, particularly human, make it a promising drug target. We have followed a chemoinformatics-based approach to identify potential drug-like inhibitors against Mycobacterium tuberculosis L-aspartate α-decarboxylase (MtbADC).

SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.

Background: Cytokinesis in many eukaryotes involves the function of an actomyosin-based contractile ring. In fission yeast, actomyosin ring maturation and stability require a conserved signaling pathway termed the SIN (septation initiation network). The SIN consists of a GTPase (Spg1p) and three protein kinases, all of which localize to the mitotic spindle pole bodies (SPBs).