Small molecule inhibitors of the VEGF and tyrosine kinase for the treatment of cervical cancer.

Cervical cancer accounts for most deaths due to cancer in women, majorly in developing nations. The culprit behind this disease is the human papillomavirus (HPV) which accounts for more than 90% of cervical cancer cases. The viral strains produce proteins that favor the knocking down of the apoptosis process and continuous growth of cells in the cervix leading to tumor growth.

Integrating advanced techniques and machine learning for landfill leachate treatment: Addressing limitations and environmental concerns.

This review article explores the challenges associated with landfill leachate resulting from the increasing disposal of municipal solid waste in landfills and open areas. The composition of landfill leachate includes antibiotics (0.001-100 μg), heavy metals (0.

Production of biopolymers from food waste: Constrains and perspectives.

Food is an essential commodity for the survival of any form of life on earth. Yet generation of plethora of food waste has significantly elevated the global concern for food scarcity, human and environment deterioration. Also, increasing use of polymers derived from petroleum hydrocarbons has elevated the concerns towards the depletion of this non-renewable resource.

Deciphering the blackbox of omics approaches and artificial intelligence in food waste transformation and mitigation.

It is necessary to stop the wastage of food during any stage of food chain to resolve the challenge of starvation, hunger and malnutrition in the world. Inception of modern techniques like omics (metagenomics, proteomics, transcriptomics, wasteomics, diseaseomics etc), enzymatic treatments, and artificial intelligence in food waste reduction and management can bring a sustainable solution for food loss management, starvation and environmental challenges. Acceptance of modern techniques while policies formulation by government bodies can substantially strengthen the idea of waste reduction, food security and can easily save the life of around 25,000 children and adults dying of starvation every day.

Characterization of a Novel Protease Inhibitor from the Edible Mushroom .

Background: Protease inhibitors inhibit the activity of protease enzymes; hence, they are essentially involved in the regulation of the metabolic processes involving protease enzymes and the protection of the host organism against external damage due to proteases. These inhibitors are abundantly present in all living organisms but have not been much reported in mushrooms. Mushrooms are one of the major food components of humans, with delicious taste and high nutritional value.

Valorization of citrus peel waste for the sustainable production of value-added products.

Globally the generation and mismanagement of waste from fruit processing and post-harvest impose a severe burden on waste management strategies along with environmental pollution, health hazards. Citrus waste is one of such worrying fruit waste, which is rich in several value-added chemicals, including pectin. Pectin is a prebiotic polysaccharide possessing a multitude of health benefits.

Protective effect of a protease inhibitor from Agaricus bisporus on Saccharomyces cerevisiae cells against oxidative stress.

Protease inhibitors are known to resist damage to host organisms against external threats, hence form a part of their defense system. This property of protease inhibitors was studied on protecting oxidatively stressed Saccharomyces cerevisiae yeast cells. The protease inhibitor was extracted from Agaricus bisporus, an edible mushroom.

Production of a protease inhibitor from edible mushroom Agaricus bisporus and its statistical optimization by response surface methodology.

The production of a protease inhibitor from Agaricus bisporus through solid-state fermentation was studied. The purpose was to produce protease inhibitor from natural, cheap, and readily available carbon and nitrogen sources. Solid-state fermentation enhanced the mycelia growth and also gave a higher yield of the product.