Clinical presentation, immunopathology, and treatment of juvenile-onset mycosis fungoides: a case series of 34 patients.

Background: Mycosis fungoides (MF), the most common form of cutaneous T-cell lymphoma, typically presents in middle-aged to elderly individuals.

Objective: We sought to study the demographics, clinicopathologic features, treatment response, and prognosis of patients with biopsy-proven MF diagnosed before 20 years of age.

Methods: Patients were identified from a prospectively collected database for retrospective analysis.

Cutaneous Crohn's disease in the pediatric population.

Three healthy children with an anogenital skin eruption, all of whom had undergone extensive medical evaluation and treatment, had undetected intestinal Crohn's disease. Biopsy of the skin showed noncaseating granulomas consistent with cutaneous Crohn's disease. Inflammatory bowel disease should be in the differential diagnosis of persistent nontender, erythematous papules, nodules, and plaques in the anogenital region.

Primary cutaneous CD30 positive anaplastic large cell lymphoma in an adolescent.

We present a case of a 14-year-old boy with a large ulcerated plaque on the scalp for 6 months, who was found to have primary cutaneous CD30-positive, anaplastic kinase-negative, anaplastic large cell lymphoma with post-auricular lymphadenopathy. MRI, bone marrow biopsy, and laboratory data demonstrated no other systemic involvement. He was treated with radiation and low-dose oral methotrexate, with improvement of the lesion and lymphadenopathy.