Publications by authors named "Reema Kashiva"
Importance: Preclinical and phase 1/2 studies with esmolol hydrochloride suggest its potential role in treatment of diabetic foot ulcers (DFUs).
Objective: To study the efficacy of topical esmolol for healing of uninfected DFUs.
Design, Setting, And Participants: A randomized, double-blind, multicenter, phase 3 clinical trial was conducted from December 26, 2018, to August 19, 2020, at 27 referral centers across India.
Article Synopsis
- The study focuses on the increase in cases of COVID-19 associated mucormycosis (CAM) during the second wave of COVID-19 in India, mainly affecting patients with diabetes.
- Conducted at Noble Hospital in Pune between April 2020 and August 2021, the research involved 59 CAM patients, revealing high mortality rates linked to factors like uncontrolled diabetes and high COVID-19 CT severity scores.
- Treatment success was achieved through surgical debridement and antifungal therapy, with 74.6% of patients recovering, highlighting the urgent need for appropriate steroid use in COVID-19 treatment to prevent complications like CAM.
Article Synopsis
- - The study evaluated the safety and efficacy of the oral drug C21 in hospitalized COVID-19 patients to see if it could reduce inflammation markers (CRP) compared to a placebo over a period of 7 days.
- - Although there was no significant difference in CRP reduction between C21 and placebo groups, a secondary analysis showed that C21 improved oxygen dependency, with more patients not requiring supplemental oxygen at day 14.
- - C21 was found to be safe and well tolerated, and the promising results regarding oxygen needs suggest further research is warranted to explore its potential benefits for hospitalized COVID-19 patients.
Cytokine release syndrome (CRS) or cytokine storm is thought to be the cause of inflammatory lung damage, worsening pneumonia and death in patients with COVID-19. Steroids (Methylprednislone or Dexamethasone) and Tocilizumab (TCZ), an interleukin-6 receptor antagonist, are approved for treatment of CRS in India. The aim of this study was to evaluate the efficacy and safety of combination therapy of TCZ and steroid in COVID-19 associated CRS.
View Article and Find Full Text PDFIntestinal malrotation is a congenital anomaly that results from an abnormality in the rotation and fixation of the gut as it returns to the abdominal cavity during development. Intussusception is a condition characterised by telescoping of one segment of the bowel into another segment. The combination of malrotation and intussusception is frequently a cause of intestinal obstruction in the paediatric age group.
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