Publications by authors named "Reema H Rachakonda"
Article Synopsis
- Escherichia coli is a leading cause of bloodstream infections and sepsis, but existing animal models fail to replicate the complexities of these conditions, hindering the development of effective treatments.
- Researchers aimed to create a more accurate large-animal model of septic shock using sheep, by infusing a specific strain of antibiotic-resistant E. coli and closely monitoring their health over 48 hours.
- The study successfully induced septic shock in five sheep, showing consistent and reproducible results, including significant drops in blood pressure and increases in lactate levels following the bacterial infusion.
Background: Packed red blood cell (pRBC) transfusion is a relatively safe and mainstay treatment commonly used in cardiac surgical patients. However, there is limited evidence on clinical effects of transfusing blood nearing end-of shelf life that has undergone biochemical changes during storage.
Objective: To investigate evidence of associations between morbidity/mortality and transfusion of blood near end of shelf-life (> 35 days) in cardiac surgical patients.
Introduction: In December 2019, the COVID-19 pandemic highlighted the urgent need for rapid collaboration, research, and interventions. International research collaborations foster more significant responses to rapid global changes by enabling international, multicentre research, decreasing biases, and increasing study validity while reducing overall research time and costs. However, there has been low uptake of collaborative research by African institutions and individuals.
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- This study examined the impact of transfusing blood products that are close to their shelf-life on clinical outcomes in obstetric patients in Queensland, Australia, from 2007 to 2013.
- Comparing fresh (less than 21 days old for RBC, less than 3 days for PLT) to old blood products (35 days or older for RBC, 4 days or older for PLT), researchers found no significant difference in patient outcomes such as hospital stay length or morbidity.
- The results indicated that using older RBC or PLT did not lead to higher rates of complications or mortality among the patients studied.