Publications by authors named "Reem Hasnah"
Objective: Food processing greatly contributed to increased food safety, diversity, and accessibility. However, the prevalence of highly palatable and highly processed food in our modern diet has exacerbated obesity rates and contributed to a global health crisis. While accumulating evidence suggests that chronic consumption of such foods is detrimental to sensory and neural physiology, it is unclear whether its short-term intake has adverse effects.
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- * Patients exhibited distinct clinical presentations, including recurrent pneumonia and hemorrhagic colitis, with the loss of the iRHOM2 protein impairing immune responses tied to cytokine release.
- * Mouse models showed that the absence of iRHOM2 resulted in increased severity of infections like pneumonia and colitis, highlighting the impact of local gut bacteria on disease outcomes.
Article Synopsis
- The study investigates childhood diabetes mellitus in Qatar, focusing on its epidemiology, genetic factors, and causes among patients aged 0-18.
- A total of 1,325 children were diagnosed with various types of diabetes, with type 1 being the most prevalent, and significantly higher incidence rates were noted in Qatari children compared to other nationalities.
- The research highlights Qatar's notable statistics regarding diabetes, including the fourth highest incidence of type 1 diabetes globally and an alarming prevalence of type 2 diabetes compared to Western countries.
Odor perception in non-humans is poorly understood. Here, we generated the most comprehensive mouse olfactory ethological atlas to date, consisting of behavioral responses to a diverse panel of 73 odorants, including 12 at multiple concentrations. These data revealed that mouse behavior is incredibly diverse and changes in response to odorant identity and concentration.
View Article and Find Full Text PDFBackground: Neonatal diabetes mellitus (NDM) is a rare condition that occurs within the first six months of life. Permanent NDM (PNDM) is caused by mutations in specific genes that are known for their expression at early and/or late stages of pancreatic beta- cell development, and are either involved in beta-cell survival, insulin processing, regulation, and release. The native population in Qatar continues to practice consanguineous marriages that lead to a high level of homozygosity.
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- - The MCT1 gene is crucial for transporting substances like lactate and pyruvate across cell membranes, and mutations can lead to severe conditions like ketoacidosis and hypoglycemia, especially affecting brain function.
- - A 28-month-old girl with MCT1 deficiency had severe hypoglycemic attacks from infancy, and genetic testing revealed a specific mutation that disrupts MCT1 function.
- - Neuroimaging showed significant brain abnormalities, indicating potential neurological issues tied to MCT1 deficiency, highlighting the need for personalized follow-up and further research on how MCT1 impacts various body systems.
Background: Natural killer (NK) cells are lymphocytes of the innate immune system that have potent cytotoxic activity against tumor cells. NK cell recognition and activity towards cancer cells are regulated by an integrated interplay between numerous inhibitory and activating receptors acting in concert to eliminate tumor cells expressing cognate ligands. Despite strong evidence supporting the role of NK cells in breast cancer (BC) control, BC still develops and progresses to form large tumors and metastases.
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