Different Chemotherapy Regimens and Pathologic Complete Response in Triple-Negative Breast Cancer: An Updated Network Meta-Analysis of Phase 3 Trials.

: Currently, the standard treatment for non-metastatic triple-negative breast cancer (TNBC) consists of a systemic neoadjuvant (or perioperative) anthracycline plus taxane-based chemotherapy, delivered either sequentially or concomitantly. We performed a network meta-analysis (NMA) to compare the relative efficacy of different neoadjuvant treatments for TNBC in terms of pathologic complete response (pCR). : The MEDLINE, Embase, and Cochrane databases were searched from database inception to 1 November 2023.

Ribociclib in the Treatment of Hormone-Receptor Positive/HER2-Negative Advanced and Early Breast Cancer: Overview of Clinical Data and Patients Selection.

Among pre- and postmenopausal women with hormone receptor-positive (HR+) breast cancer (BC), combinations of an aromatase inhibitor (AI) or fulvestrant with a CDK 4/6 inhibitor (palbociclib, ribociclib, or abemaciclib) have demonstrated improved progression-free survival (PFS) and overall survival (OS) compared to standard single-agent hormone therapy alone as first-line therapy for de novo metastatic disease or relapse during or after adjuvant therapy and no previous therapies in an advanced setting. We here reviewed clinical data about ribociclib in advanced and early BC. Also, we shed light on patient selection and special settings in which medical oncologists urgently await an advance in treatment.

[Surgical treatment of Crohn's disease. Indication and management in 20 patients].

Materials And Methods: Sixty-seven patients with Crohn's disease underwent surgery in our department in the period 1989-1996. In this paper we evaluated only the first 20 patients. Ten were female and 10 male.

[A gastrocutaneous fistula secondary to the percutaneous drainage of a pancreatic abscess. A case report].

Pancreatic abscesses are a frequent complication of acute pancreatitis and their percutaneous drainage is usually accepted. A 76 years-old male patient admitted for acute pancreatitis (Ranson 3 at admission) has been treated with conservative therapy and percutaneous US directed drainage of the abscess, located between the tail of the pancreas and the gastric fundus. This kind of drainage was able to empty the abscess satisfactorily but it caused the onset of a gastrocutaneous fistula.

Intraoperative colonic lavage in emergency surgical treatment of left-sided colonic obstruction.

Purpose: The study contained herein was undertaken to verify if immediate resection with anastomosis with on-site lavage in emergency treatment of left colon obstruction is a safe alternative to the multistage procedure, to look for solutions to practical problems outlined by previous authors, and to check the hospital stay.

Method: Between 1991 and 1995, all patients (61) admitted with left colon obstruction were treated with intraoperative colonic lavage and primary anastomosis. Personal development of Dudley's technique is reported.

[Metastasis and hepatic resection surgery. Our experience].

The authors' experience of the surgical management of liver metastasis is discussed. Failure in preoperative assessment influenced surgical procedures and led to questionable choices. However morbidity and mortality were rather good.